TRAP-6 | CAS#141136-83-6 | PAR1 agonist

TRAP-6
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561531

CAS#: 141136-83-6

Description: TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. TRAP-6 stimulates platelet aggregation, promotes intracellular Ca2+ mobilization, and induces rapid phosphodiesterase 3A (PDE3A).

Chemical Structure

TRAP-6

CAS# 141136-83-6

Instruction

Theoretical Analysis

MedKoo Cat#: 561531
Name: TRAP-6
CAS#: 141136-83-6
Chemical Formula: C34H56N10O9
Exact Mass: 748.42
Molecular Weight: 748.880
Elemental Analysis: C, 54.53; H, 7.54; N, 18.70; O, 19.23

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 495
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: TRAP-6; TRAP 6; TRAP6; Thrombin receptor activator peptide 6; SFLLRN; SFLLRN-OH; Ser-Phe-Leu-Leu-Arg-Asn;

IUPAC/Chemical Name: L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine

InChi Key: HAGOWCONESKMDW-FRSCJGFNSA-N

InChi Code: InChI=1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

SMILES Code: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)[C@H](CO)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 748.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Schimmer C, Hamouda K, Sommer SP, Özkur M, Hain J, Leyh R. The predictive value of multiple electrode platelet aggregometry (multiplate) in adult cardiac surgery. Thorac Cardiovasc Surg. 2013 Dec;61(8):733-43. doi: 10.1055/s-0033-1333659. Epub 2013 Feb 18. Review. PubMed PMID: 23420333.

2: Smadja DM, Gaussem P. [Characterization of endothelial progenitor cells and putative strategies to improve their expansion]. J Soc Biol. 2009;203(2):197-207. doi: 10.1051/jbio/2009024. Epub 2009 Jun 16. Review. French. PubMed PMID: 19527634.

3: Smadja DM, Cornet A, Emmerich J, Aiach M, Gaussem P. Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy. Cell Biol Toxicol. 2007 Jul;23(4):223-39. Epub 2007 Mar 16. Review. PubMed PMID: 17370127.

4: Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK. Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):13-36. Review. PubMed PMID: 15317288.

5: Poullis M, Landis RC, Taylor KM. Aprotinin: is it prothrombotic? Perfusion. 2001 Sep;16(5):401-9. Review. PubMed PMID: 11565895.

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