Neuromedin N

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MedKoo CAT#: 561530

CAS#: 92169-45-4

Description: Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin. It binds to neurotensin receptors to regulate guinea pig intestinal smooth muscle contraction. It also produces hypotension in rats and induces hypothermia following central administration in rats in vivo.


Price and Availability

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Pricing updated 2020-10-22. Prices are subject to change without notice.

Neuromedin N is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561530
Name: Neuromedin N
CAS#: 92169-45-4
Chemical Formula: C38H63N7O8
Exact Mass: 745.4738
Molecular Weight: 745.96
Elemental Analysis: C, 61.19; H, 8.51; N, 13.14; O, 17.16


Synonym: Neuromedin N; Neuromedin-N; KIPYIL; Lys-Ile-Pro-Tyr-Ile-Leu; H-Lys-Ile-Pro-Tyr-Ile-Leu-OH;

IUPAC/Chemical Name: L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

InChi Key: RZMLVIHXZGQADB-YLUGYNJDSA-N

InChi Code: InChI=1S/C38H63N7O8/c1-7-23(5)31(36(50)42-29(38(52)53)20-22(3)4)43-34(48)28(21-25-14-16-26(46)17-15-25)41-35(49)30-13-11-19-45(30)37(51)32(24(6)8-2)44-33(47)27(40)12-9-10-18-39/h14-17,22-24,27-32,46H,7-13,18-21,39-40H2,1-6H3,(H,41,49)(H,42,50)(H,43,48)(H,44,47)(H,52,53)/t23-,24-,27-,28-,29-,30-,31-,32-/m0/s1

SMILES Code: O=C(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)[C@H](CCCCN)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Fuxe K, Tarakanov A, Romero Fernandez W, Ferraro L, Tanganelli S, Filip M, Agnati LF, Garriga P, Diaz-Cabiale Z, Borroto-Escuela DO. Diversity and Bias through Receptor-Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization. Front Endocrinol (Lausanne). 2014 May 13;5:71. doi: 10.3389/fendo.2014.00071. eCollection 2014. Review. PubMed PMID: 24860548; PubMed Central PMCID: PMC4026686.

2: Kitabgi P. Neurotensin and neuromedin N are differentially processed from a common precursor by prohormone convertases in tissues and cell lines. Results Probl Cell Differ. 2010;50:85-96. doi: 10.1007/400_2009_27. Review. PubMed PMID: 19862492.

3: Kitabgi P. Inactivation of neurotensin and neuromedin N by Zn metallopeptidases. Peptides. 2006 Oct;27(10):2515-22. Epub 2006 Aug 9. Review. PubMed PMID: 16904239.

4: Kitabgi P. Differential processing of pro-neurotensin/neuromedin N and relationship to pro-hormone convertases. Peptides. 2006 Oct;27(10):2508-14. Epub 2006 Aug 9. Review. PubMed PMID: 16904237.

5: Kitabgi P. Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines. J Mol Med (Berl). 2006 Aug;84(8):628-34. Epub 2006 May 11. Review. PubMed PMID: 16688434.

6: Kinkead B, Nemeroff CB. Novel treatments of schizophrenia: targeting the neurotensin system. CNS Neurol Disord Drug Targets. 2006 Apr;5(2):205-18. Review. PubMed PMID: 16611093.

7: Costentin J. [Pain and its main transmitters]. Ann Pharm Fr. 2000 Mar;58(2):77-83. Review. French. PubMed PMID: 10790600.

8: Kinkead B, Binder EB, Nemeroff CB. Does neurotensin mediate the effects of antipsychotic drugs? Biol Psychiatry. 1999 Aug 1;46(3):340-51. Review. PubMed PMID: 10435199.

9: Vincent JP. Neurotensin receptors: binding properties, transduction pathways, and structure. Cell Mol Neurobiol. 1995 Oct;15(5):501-12. Review. PubMed PMID: 8719037.

10: Kitabgi P, De Nadai F, Rovère C, Bidard JN. Biosynthesis, maturation, release, and degradation of neurotensin and neuromedin N. Ann N Y Acad Sci. 1992;668:30-42. Review. PubMed PMID: 1463273.

11: Dobner PR, Kislauskis E, Bullock BP. Cooperative regulation of neurotensin/neuromedin N gene expression in PC12 cells involves AP-1 transcription factors. Ann N Y Acad Sci. 1992;668:17-29. Review. PubMed PMID: 1463270.

12: Carraway RE, Mitra SP, Spaulding G. Posttranslational processing of the neurotensin/neuromedin-N precursor. Ann N Y Acad Sci. 1992;668:1-16. Review. PubMed PMID: 1463268.