ORC-13661 HCl

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MedKoo CAT#: 530975

CAS#: 1589571-77-6 (HCl)

Description: ORC-13661, also known as BPN-13661, is a Potent, Well Tolerated and Orally Active Protective Agents Against Aminoglycoside-Induced Hearing Loss. ORC-13661 protects mechanosensory hair cells with HC50 of 120 nM and demonstrated 100% protection in the zebrafish assay, superior physiochemical and pharmacokinetic and toxicologic properties as well as complete in vivo protection in rats. ORC-13661 is being developed by Oricula Therapeutics.


Chemical Structure

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ORC-13661 HCl
CAS# 1589571-77-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 530975
Name: ORC-13661 HCl
CAS#: 1589571-77-6 (HCl)
Chemical Formula: C18H20Cl2N4O2S
Exact Mass: 0.00
Molecular Weight: 427.344
Elemental Analysis: C, 50.59; H, 4.72; Cl, 16.59; N, 13.11; O, 7.49; S, 7.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1589573-55-6 (free base)   1589571-77-6 (HCl)   1589573-53-4 (free base)   1589571-74-3 (HCl)   1589573-54-5 (free base rotation (-))   1589571-76-5 (HClrotation (-))    

Synonym: ORC-13661; ORC 13661; ORC13661; BPN-13661; BPN 13661; BPN13661.

IUPAC/Chemical Name: (8S)-2-(3-(4-chlorophenyl)ureido)-9-methyl-5,6,7,8-tetrahydro-4H-5,8-epiminocyclohepta[b]thiophene-3-carboxamide hydrochloride

InChi Key: AILAJXCIBMDGMN-IYWIJXFJSA-N

InChi Code: InChI=1S/C18H19ClN4O2S.ClH/c1-23-11-6-7-13(23)15-12(8-11)14(16(20)24)17(26-15)22-18(25)21-10-4-2-9(19)3-5-10;/h2-5,11,13H,6-8H2,1H3,(H2,20,24)(H2,21,22,25);1H/t11?,13-;/m0./s1

SMILES Code: O=C(C1=C(NC(NC2=CC=C(Cl)C=C2)=O)SC3=C1CC4CC[C@@H]3N4C)N.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 427.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chowdhury S, Owens KN, Herr RJ, Jiang Q, Chen X, Johnson G, Groppi VE, Raible
DW, Rubel EW, Simon JA. Phenotypic Optimization of Urea-Thiophene Carboxamides to
Yield Potent, Well Tolerated and Orally Active Protective Agents Against
Aminoglycoside-Induced Hearing Loss. J Med Chem. 2017 Oct 9. doi:
10.1021/acs.jmedchem.7b00932. [Epub ahead of print] PubMed PMID: 28992413.