(±)-Necrostatin-2
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MedKoo CAT#: 530971

CAS#: 852391-15-2 (racemic)

Description: Necrostatin-2, also known as (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s, is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 235 2 Weeks
10mg USD 365 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-23. Prices are subject to change without notice.

(±)-Necrostatin-2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530971
Name: (±)-Necrostatin-2
CAS#: 852391-15-2 (racemic)
Chemical Formula: C13H12ClN3O2
Exact Mass: 277.0618
Molecular Weight: 277.708
Elemental Analysis: C, 56.23; H, 4.36; Cl, 12.77; N, 15.13; O, 11.52


Related CAS #: 852391-19-6 (R-isomer)   852391-15-2 (racemic)    

Synonym: Necrostatin-2; (±)-Necrostatin-2; 7-Cl-O-Nec-1; Nec-1s;

IUPAC/Chemical Name: 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

InChi Key: WIKGAEMMNQTUGL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)

SMILES Code: O=C1N(C)C(C(CC2=CNC3=C2C=CC=C3Cl)N1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assa C,
Kent KC, Liu B. Inhibition of Receptor-Interacting Protein Kinase 1 with
Necrostatin-1s ameliorates disease progression in elastase-induced mouse
abdominal aortic aneurysm model. Sci Rep. 2017 Feb 10;7:42159. doi:
10.1038/srep42159. PubMed PMID: 28186202; PubMed Central PMCID: PMC5301478.

2: Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H.
Necrostatin-1 rescues mice from lethal irradiation. Biochim Biophys Acta. 2016
Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. Epub 2016 Jan 20. PubMed
PMID: 26802452; PubMed Central PMCID: PMC4788560.

3: Berger SB, Harris P, Nagilla R, Kasparcova V, Hoffman S, Swift B, Dare L,
Schaeffer M, Capriotti C, Ouellette M, King BW, Wisnoski D, Cox J, Reilly M,
Marquis RW, Bertin J, Gough PJ. Characterization of GSK'963: a structurally
distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015
Jul 27;1:15009. doi: 10.1038/cddiscovery.2015.9. eCollection 2015. PubMed PMID:
27551444; PubMed Central PMCID: PMC4979471.