WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571352
Description: ABD-295 is an antiresorptive agent, osteoclast inhibitor, and novel biphenylsulfide derivative with potent inhibitory effects on osteoclastic bone resorption in vitro. It has been shown to prevent ovariectomy-induced bone loss in vivo.
MedKoo Cat#: 571352
Chemical Formula: C17H19F2NO3S
Exact Mass: 355.1054
Molecular Weight: 355.4
Elemental Analysis: C, 57.45; H, 5.39; F, 10.69; N, 3.94; O, 13.51; S, 9.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: ABD-295; ABD295; ABD 295
IUPAC/Chemical Name: (1,1'-Biphenyl)-4-sulfonamide, 2',4'-difluoro-N-(4-hydroxybutyl)-2-methyl-
InChi Key: TYHUSNQWWKFBCU-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H19F2NO3S/c1-12-10-14(24(22,23)20-8-2-3-9-21)5-7-15(12)16-6-4-13(18)11-17(16)19/h4-7,10-11,20-21H,2-3,8-9H2,1H3
SMILES Code: O=S(C1=CC=C(C2=CC=C(F)C=C2F)C(C)=C1)(NCCCCO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 355.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Greig IR, Idris AI, Ralston SH, van't Hof RJ. Development and characterization of biphenylsulfonamides as novel inhibitors of bone resorption. J Med Chem. 2006 Dec 14;49(25):7487-92. PubMed PMID: 17149877.