WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561527

CAS#: 406228-58-8

Description: A-371191 is a novel Bcl-XL antagonist. Bcl-XL is one of the anti-apoptotic Bcl-2 family members that plays a key role in the regulation of apoptosis. Overexpression of Bcl-XL occurs in numerous cancers and its overexpression correlates with increased resistance to many chemocytotoxic drugs.

Price and Availability




A-371191 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 561527
Name: A-371191
CAS#: 406228-58-8
Chemical Formula: C36H47N5O5S2
Exact Mass: 693.3019
Molecular Weight: 693.92
Elemental Analysis: C, 62.31; H, 6.83; N, 10.09; O, 11.53; S, 9.24

Synonym: A-371191; A 371191; A371191;

IUPAC/Chemical Name: 4-(8-Azaspiro(4.5)dec-8-yl)-N-((4-(((1R)-5-(dimethylamino)-1-((phenylthio)methyl)pentyl)amino)-3-nitrophenyl)sulfonyl)-benzamide


InChi Code: InChI=1S/C36H47N5O5S2/c1-39(2)23-9-6-10-29(27-47-31-11-4-3-5-12-31)37-33-18-17-32(26-34(33)41(43)44)48(45,46)38-35(42)28-13-15-30(16-14-28)40-24-21-36(22-25-40)19-7-8-20-36/h3-5,11-18,26,29,37H,6-10,19-25,27H2,1-2H3,(H,38,42)/t29-/m1/s1

SMILES Code: O=C(NS(=O)(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CCCCN(C)C)C([N+]([O-])=O)=C1)=O)C3=CC=C(N(CC4)CCC54CCCC5)C=C3

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Stephen K. Tahir, Robert B. Warner, Jang Y. Lee, Mary K. Joseph, Haichao Zhang, Paul Nimmer, William J. McClellan, Wang Shen, Saul H. Rosenberg and Shi-Chung Ng. Biological effects of A-371191, a novel Bcl-XL antagonist. DOI: Published April 2004. Experimental and Molecular Therapeutics 45: Small Molecules: Signaling and Apoptosis Targets.