WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530962

CAS#: 313984-77-9

Description: PU-02 is a potent and selective 5-HT3 receptor antagonist. PU02 displays IC(50) values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. In an elaborate mutagenesis study of the 5-HT(3)A receptor guided by a homology model, PU02 is demonstrated to act through a transmembrane intersubunit site situated in the upper three helical turns of TM2 and TM3 in the (+)-subunit and TM1 and TM2 in the (-)-subunit.

Chemical Structure

CAS# 313984-77-9

Theoretical Analysis

MedKoo Cat#: 530962
Name: PU-02
CAS#: 313984-77-9
Chemical Formula: C16H12N4S
Exact Mass: 292.0783
Molecular Weight: 292.36
Elemental Analysis: C, 65.73; H, 4.14; N, 19.16; S, 10.97

Price and Availability

Size Price Availability Quantity
10.0mg USD 250.0 2 Weeks
25.0mg USD 550.0 2 Weeks
50.0mg USD 950.0 2 Weeks
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Synonym: PU-02; PU 02; PU02.

IUPAC/Chemical Name: 6-[(1-naphthylmethyl)thio]-9H-purine


InChi Code: InChI=1S/C16H12N4S/c1-2-7-13-11(4-1)5-3-6-12(13)8-21-16-14-15(18-9-17-14)19-10-20-16/h1-7,9-10H,8H2,(H,17,18,19,20)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 292.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Trattnig SM, Harpsøe K, Thygesen SB, Rahr LM, Ahring PK, Balle T, Jensen AA.
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and
potentiation of Cys-loop receptor signaling through a conserved transmembrane
intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54. doi:
10.1074/jbc.M112.360370. Epub 2012 May 15. PubMed PMID: 22589534; PubMed Central
PMCID: PMC3408183.


10.0mg / USD 250.0