WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530962
CAS#: 313984-77-9
Description: PU-02 is a potent and selective 5-HT3 receptor antagonist. PU02 displays IC(50) values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. In an elaborate mutagenesis study of the 5-HT(3)A receptor guided by a homology model, PU02 is demonstrated to act through a transmembrane intersubunit site situated in the upper three helical turns of TM2 and TM3 in the (+)-subunit and TM1 and TM2 in the (-)-subunit.
MedKoo Cat#: 530962
Name: PU-02
CAS#: 313984-77-9
Chemical Formula: C16H12N4S
Exact Mass: 292.0783
Molecular Weight: 292.36
Elemental Analysis: C, 65.73; H, 4.14; N, 19.16; S, 10.97
Synonym: PU-02; PU 02; PU02.
IUPAC/Chemical Name: 6-[(1-naphthylmethyl)thio]-9H-purine
InChi Key: BGMSTNYJYPSLHN-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H12N4S/c1-2-7-13-11(4-1)5-3-6-12(13)8-21-16-14-15(18-9-17-14)19-10-20-16/h1-7,9-10H,8H2,(H,17,18,19,20)
SMILES Code: C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 292.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Trattnig SM, Harpsøe K, Thygesen SB, Rahr LM, Ahring PK, Balle T, Jensen AA.
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and
potentiation of Cys-loop receptor signaling through a conserved transmembrane
intersubunit site. J Biol Chem. 2012 Jul 20;287(30):25241-54. doi:
10.1074/jbc.M112.360370. Epub 2012 May 15. PubMed PMID: 22589534; PubMed Central
PMCID: PMC3408183.
