WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571348

CAS#: 27035-30-9

Description: Oxametacin is a anti-inflammatory compound used with care in anticoagulated patients. It has analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin.

Chemical Structure

CAS# 27035-30-9

Theoretical Analysis

MedKoo Cat#: 571348
Name: Oxametacin
CAS#: 27035-30-9
Chemical Formula: C19H17ClN2O4
Exact Mass: 372.0877
Molecular Weight: 372.81
Elemental Analysis: C, 61.21; H, 4.60; Cl, 9.51; N, 7.51; O, 17.17

Price and Availability

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250.0mg USD 550.0 2 Weeks
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Synonym: Oxametacin

IUPAC/Chemical Name: 1-p-chlorobenzoyl-5-methoxy-2-methyl-3-indoacetohydroxamic acid


InChi Code: InChI=1S/C19H17ClN2O4/c1-11-15(10-18(23)21-25)16-9-14(26-2)7-8-17(16)22(11)19(24)12-3-5-13(20)6-4-12/h3-9,25H,10H2,1-2H3,(H,21,23)

SMILES Code: O=C(NO)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 372.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Polderman J, Colon M. General practitioners' evaluation of side-effects and efficacy of oxamethacin as compared with indomethacin. J Int Med Res. 1980;8(2):156-62. PubMed PMID: 6989685.

2: Polderman J, Colon M. Oxamethacin: a pilot field survey. J Int Med Res. 1979;7(1):83-9. PubMed PMID: 154426.

3: Bröll H, Kocsis F. [Studies on the possible influence of oxamethacin upon DNA synthesis, DNA reparation and the supercoiled structure of DNA is spleen cells of mice]. Z Rheumatol. 1980 Nov-Dec;39(11-12):401-5. German. PubMed PMID: 7282104.

4: Gavioli R, Spisani S, Cavalletti T, Marangoni C, Traniello S. [Indomethacin and oxamethacin as modulators of the production of superoxide anion in human leukocytes]. Boll Soc Ital Biol Sper. 1984 Jun 30;60(6):1095-101. Italian. PubMed PMID: 6089851.

5: Damas J, Volon G. [Effect of oxamethacin and sulindac on prostaglandin synthesis]. C R Seances Soc Biol Fil. 1979;173(4):849-53. French. PubMed PMID: 160831.

6: Verhaegen H. Activity and tolerance of oxamethacin. Methods Find Exp Clin Pharmacol. 1982;4(8):617-23. PubMed PMID: 6763119.

7: Spisani S, Marangoni C, Traniello S. Effect of anti-inflammatory drugs on leukocyte superoxide production by soluble and particulate stimuli. Biochem Int. 1984 Jul;9(1):1-8. PubMed PMID: 6089834.

8: Spisani S, Marangoni C, Dovigo L, Traniello S. Effect of antiinflammatory agents on neutrophil superoxide production in rheumatoid arthritis. Inflammation. 1984 Mar;8(1):45-52. PubMed PMID: 6325344.

9: Perdrix, Sahakian. [A new non-steroidal anti-inflammatory agent in periodontology, oxametacine (a study of 85 cases)]. Inf Dent. 1984 Nov 8;66(39):3955-9. French. PubMed PMID: 6597800.

10: Broekhuysen J, Deger F, Douchamps J, Ducarne H, Herchuelz A, Polderman J. Effect of oxametacin on endogenous uric acid clearance rate in healthy volunteers. Eur J Clin Pharmacol. 1983;24(5):671-3. PubMed PMID: 6873149.

11: Franzone J, Natale T, Negro F, Curzio M, Torrielli MV, Sena LM. [Influence of thyroid states on PGE2 biosynthesis]. Boll Soc Ital Biol Sper. 1981 Mar 30;57(6):604-9. Italian. PubMed PMID: 6944075.

12: Sena L, Torrielli MV, Franzone J, Curzio M, Cirillo R. The influence of experimental hypo- and hyperthyroid states on acute and chronic inflammatory reactions: modified response to non-steroidal anti-inflammatory agents. J Pathol. 1981 Sep;135(1):9-17. PubMed PMID: 7299530.

13: Marangoni C, Spisani S, Dovigo L, Traniello S. [Regulation of the functions of human leukocytes by oxametacine]. Boll Soc Ital Biol Sper. 1982 Nov 15;58(21):1413-8. Italian. PubMed PMID: 6297524.

14: Vergin H, Strobel K, Szelenyi I. Distribution of oxametacine and its anti-inflammatory metabolites in inflamed tissues of rats. Agents Actions. 1983 Jun;13(4):364-7. PubMed PMID: 6613750.

15: Baele G, Rasquin K, Barbier F. Effects of oxametacin on coumarin anticoagulation and on platelet function in humans. Arzneimittelforschung. 1983;33(1):149-52. PubMed PMID: 6681967.

16: Franzone JS, Natale T, Cirillo R. Effect of a new anti-inflammatory drug (oxametacine) on the prostaglandin biosynthesis. Farmaco Sci. 1980 Jun;35(6):498-503. PubMed PMID: 6778714.

17: Franzone JS, Coluccia A, Reboani MC. Influence of oxamethacin on oriented migration of rat polymorphonuclear leucocytes. Int J Tissue React. 1983;5(1):29-34. PubMed PMID: 6862788.

18: Vergin H, Ferber H, Brunner F, Kukovetz WR. [Pharmacokinetics and biotransformation of oxametacine in healthy volunteers (author's transl)]. Arzneimittelforschung. 1981;31(3):513-8. German. PubMed PMID: 7194675.

19: Dittrich P, Ferber H, Vergin H, Kukovetz WR. [Pharmacokinetics of oxametacin in healthy volunteers following multiple administration (author's transl)]. Arzneimittelforschung. 1981;31(3):518-23. German. PubMed PMID: 7194676.


250.0mg / USD 550.0