ODQ inhibitor
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MedKoo CAT#: 561513

CAS#: 41443-28-1

Description: ODQ potent and selective inhibitor of soluble guanylyl cyclase (sGC). The binding of ODQ is competitive with NO.


Chemical Structure

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ODQ inhibitor
CAS# 41443-28-1

Theoretical Analysis

MedKoo Cat#: 561513
Name: ODQ inhibitor
CAS#: 41443-28-1
Chemical Formula: C9H5N3O2
Exact Mass: 187.0382
Molecular Weight: 187.15
Elemental Analysis: C, 57.76; H, 2.69; N, 22.45; O, 17.10

Price and Availability

Size Price Availability Quantity
100.0mg USD 850.0 2 Weeks
200.0mg USD 1350.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 5650.0 2 Weeks
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Synonym: ODQ;

IUPAC/Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

InChi Key: LZMHWZHOZLVYDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H

SMILES Code: O=C1ON=C2N1C3=C(C=CC=C3)N=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 187.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 1995 Aug;48(2):184-8. PubMed PMID: 7544433.

2: Schrammel A, Behrends S, Schmidt K, Koesling D, Mayer B. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol. 1996 Jul;50(1):1-5. PubMed PMID: 8700100.