WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561513
Description: ODQ potent and selective inhibitor of soluble guanylyl cyclase (sGC). The binding of ODQ is competitive with NO.
MedKoo Cat#: 561513
Name: ODQ inhibitor
Chemical Formula: C9H5N3O2
Exact Mass: 187.0382
Molecular Weight: 187.15
Elemental Analysis: C, 57.76; H, 2.69; N, 22.45; O, 17.10
IUPAC/Chemical Name: 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
InChi Key: LZMHWZHOZLVYDL-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
SMILES Code: O=C1ON=C2N1C3=C(C=CC=C3)N=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 187.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 1995 Aug;48(2):184-8. PubMed PMID: 7544433.
2: Schrammel A, Behrends S, Schmidt K, Koesling D, Mayer B. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol. 1996 Jul;50(1):1-5. PubMed PMID: 8700100.