EY3238

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407836

CAS#: 1995861-12-5

Description: EY3238 is a JAK2-HDAC dual inhibitor with low nanomolar activity against JAK2 and HDAC6 while also inhibiting HDACs 2 and 10 with IC50 values below 100 nM (JAK2 IC50 = 1.4 nM); HDAC6 IC50 = 2.1 nM; HDAC2 IC50 = 49nM; HDAC10 IC50 = 80 nM.).


Chemical Structure

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EY3238
CAS# 1995861-12-5

Theoretical Analysis

MedKoo Cat#: 407836
Name: EY3238
CAS#: 1995861-12-5
Chemical Formula: C29H34N4O5
Exact Mass: 518.25
Molecular Weight: 518.614
Elemental Analysis: C, 67.16; H, 6.61; N, 10.80; O, 15.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: EY3238; EY-3238; EY 3238.

IUPAC/Chemical Name: (E)-7-(6,11-dioxa-3-aza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-en-44-yloxy)-N-hydroxyheptanamide

InChi Key: IYBYMTCQQMFOHB-AATRIKPKSA-N

InChi Code: InChI=1S/C29H34N4O5/c34-28(33-35)10-3-1-2-4-17-38-27-12-11-25-19-24(27)21-37-16-6-5-15-36-20-22-8-7-9-23(18-22)26-13-14-30-29(31-25)32-26/h5-9,11-14,18-19,35H,1-4,10,15-17,20-21H2,(H,33,34)(H,30,31,32)/b6-5+

SMILES Code: O=C(NO)CCCCCCOC1=CC=C2C=C1COC/C=C/COCC3=CC=CC(C4=NC(N2)=NC=C4)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 518.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yang, E. G.; Mustafa, N.; Tan, E. C.; Poulsen, A.; Ramanujulu, P. M.; Chng, W. J.; Yen, J. J.; Dymock, B. W. Design and synthesis of janus kinase 2 (JAK2) and histone deacetlyase (HDAC) bispecific inhibitors based on pacritinib and evidence of dual pathway inhibition in hematological cell lines. J. Med. Chem. 2016, 59, 8233−8262.

2. Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
Lianbin Yao, Nurulhuda Mustafa, Eng Chong Tan, Anders Poulsen, Prachi Singh, Minh-Dao Duong-Thi, Jeannie X. T. Lee, Pondy Murugappan Ramanujulu, Wee Joo Chng, Jeffrey J. Y. Yen, Sten Ohlson, and Brian W. Dymock
Publication Date (Web): September 27, 2017 (Article)
DOI: 10.1021/acs.jmedchem.7b00678