ATH686

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407832

CAS#: 853299-52-2

Description: ATH686 is a potent and selective FLT3 Inhibitor. ATH686 highlights a new class of highly potent FLT3 inhibitors able to override drug resistance that less potent "type I" inhibitors and "type II" first-generation FLT3 inhibitors cannot.


Chemical Structure

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ATH686
CAS# 853299-52-2

Theoretical Analysis

MedKoo Cat#: 407832
Name: ATH686
CAS#: 853299-52-2
Chemical Formula: C25H28F3N7O2
Exact Mass: 515.23
Molecular Weight: 515.541
Elemental Analysis: C, 58.24; H, 5.47; F, 11.06; N, 19.02; O, 6.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ATH686; ATH-686; ATH 686.

IUPAC/Chemical Name: 1-[4-(2-Amino-pyrimidin-4-yloxy)-phenyl]-3-[4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenyl]-urea

InChi Key: VQQRBBFRJRBWPF-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28F3N7O2/c1-2-34-11-13-35(14-12-34)16-17-3-4-19(15-21(17)25(26,27)28)32-24(36)31-18-5-7-20(8-6-18)37-22-9-10-30-23(29)33-22/h3-10,15H,2,11-14,16H2,1H3,(H2,29,30,33)(H2,31,32,36)

SMILES Code: O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Constitutively activated mutant FLT3 has emerged as a promising target for therapy for the subpopulation of acute myeloid leukemia (AML) patients who harbor it.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 515.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Weisberg E, Roesel J, Furet P, Bold G, Imbach P, Flörsheimer A, Caravatti G,
Jiang J, Manley P, Ray A, Griffin JD. Antileukemic Effects of Novel First- and
Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer.
2010 Oct;1(10):1021-32. doi: 10.1177/1947601910396505. PubMed PMID: 21779428;
PubMed Central PMCID: PMC3092267.