Galanthaminone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329851

CAS#: 510-77-0

Description: Galanthaminone is a cholinesterase (AChE) inhibitor for the treatment of mild to moderate Alzheimer's disease.

Chemical Structure

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Galanthaminone
CAS# 510-77-0
Instruction

Theoretical Analysis

MedKoo Cat#: 329851
Name: Galanthaminone
CAS#: 510-77-0
Chemical Formula: C17H19NO3
Exact Mass: 285.14
Molecular Weight: 285.343
Elemental Analysis: C, 71.56; H, 6.71; N, 4.91; O, 16.82

Price and Availability

Size Price Availability Quantity
5mg USD 385 2 weeks
10mg USD 685 2 Weeks
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Synonym: Galanthaminone; (-)-Narwedine; Narwedine; 3-Deoxy-3-oxo-galanthamine;

IUPAC/Chemical Name: (4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one

InChi Key: QENVUHCAYXAROT-YOEHRIQHSA-N

InChi Code: InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1

SMILES Code: O=C1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 285.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bickel U, Thomsen T, Weber W, Fischer JP, Bachus R, Nitz M, Kewitz H.
Pharmacokinetics of galanthamine in humans and corresponding cholinesterase
inhibition. Clin Pharmacol Ther. 1991 Oct;50(4):420-8. PubMed PMID: 1914378.


2: Thomsen T, Bickel U, Fischer JP, Kewitz H. Stereoselectivity of cholinesterase
inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol.
1990;39(6):603-5. PubMed PMID: 2095347.


3: Mihailova D, Yamboliev I, Zhivkova Z, Tencheva J, Jovovich V. Pharmacokinetics
of galanthamine hydrobromide after single subcutaneous and oral dosage in humans.
Pharmacology. 1989;39(1):50-8. PubMed PMID: 2587617.


4: Mihailova D, Velkov M, Zhivkova Z. In vitro metabolism of galanthamine
hydrobromide (Nivalin) by rat and rabbit liver homogenate. Eur J Drug Metab
Pharmacokinet. 1987 Jan-Mar;12(1):25-30. PubMed PMID: 3609070.


5: KOIZUMI J, KOBAYASHI S, UYEO S. GALANTHAMINE CHEMISTRY. V. FORMATION OF
HYDROXYAPOGALANTHAMINE FROM GALANTHAMINONE AND THE SYNTHESIS OF ITS TRIMETHYL
ETHER. Chem Pharm Bull (Tokyo). 1964 Jun;12:696-705. PubMed PMID: 14199166.