NAAD sodium salt
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MedKoo CAT#: 561492

CAS#: 104809-30-5

Description: NAAD sodium salt initiates intracellular Ca2+ release by a cyclic ADP ribose-independent and IP3 mechanism. It is also used as a substrate to study the specificity and kinetics of nicotinamide adenine dinucleotide synthetase(s) (NADS).


Price and Availability

Size Price Shipping out time Quantity
25mg USD 255 2 Weeks
100mg USD 580 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-20. Prices are subject to change without notice.

NAAD sodium salt is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561492
Name: NAAD sodium salt
CAS#: 104809-30-5
Chemical Formula: C21H25N6NaO15P2
Exact Mass:
Molecular Weight: 686.39
Elemental Analysis: C, 36.75; H, 3.67; N, 12.24; Na, 3.35; O, 34.96; P, 9.03


Synonym: NAAD sodium salt; NAAD Na salt; NAAD Na, NaAD; Deamido Nad Sodium Salt; Nicotinic acid adenine dinucleotide sodium salt;

IUPAC/Chemical Name: Sodium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3S,4R,5R)-5-(3-carboxypyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

InChi Key: LFHLUTZTSGEADU-RHANTIMGSA-M

InChi Code: InChI=1S/C21H26N6O15P2.Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(31)14(29)11(41-20)6-39-44(36,37)42-43(34,35)38-5-10-13(28)15(30)19(40-10)26-3-1-2-9(4-26)21(32)33;/h1-4,7-8,10-11,13-16,19-20,28-31H,5-6H2,(H4-,22,23,24,32,33,34,35,36,37);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,19-,20-;/m1./s1

SMILES Code: O=P(OP([O-])(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)=O)([O-])OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@H](O)[C@@H]4O.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. PubMed PMID: 15793621.

2: Patel S, Churchill GC, Galione A. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. PubMed PMID: 11104679; PubMed Central PMCID: PMC1221510.