WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329845

CAS#: 2478-38-8

Description: Acetosyringone is a phenolic natural product, and is a chemical compound related to acetophenone and 2,6-dimethoxyphenol. It was first described in relation to lignan/phenylpropanoid-type phytochemicals, with isolation from a variety of plant sources, in particular, in relation to wounding and other physiologic changes.

Price and Availability


USD 265

USD 465

USD 750

Acetosyringone, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 329845
Name: Acetosyringone
CAS#: 2478-38-8
Chemical Formula: C10H12O4
Exact Mass: 196.0736
Molecular Weight: 196.202
Elemental Analysis: C, 61.22; H, 6.17; O, 32.62

Synonym: Acetosyringone

IUPAC/Chemical Name: 4'-Hydroxy-3',5'-dimethoxyacetophenone


InChi Code: InChI=1S/C10H12O4/c1-6(11)7-4-8(13-2)10(12)9(5-7)14-3/h4-5,12H,1-3H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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2: Manfroi E, Yamazaki-Lau E, Grando MF, Roesler EA. Acetosyringone, pH and temperature effects on transient genetic transformation of immature embryos of Brazilian wheat genotypes by Agrobacterium tumefaciens. Genet Mol Biol. 2015 Dec;38(4):470-6. doi: 10.1590/S1415-475738420150026. Epub 2015 Nov 3. PubMed PMID: 26537604; PubMed Central PMCID: PMC4763325.

3: Srinivasan R, Gothandam KM. Synergistic Action of D-Glucose and Acetosyringone on Agrobacterium Strains for Efficient Dunaliella Transformation. PLoS One. 2016 Jun 28;11(6):e0158322. doi: 10.1371/journal.pone.0158322. eCollection 2016. PubMed PMID: 27351975; PubMed Central PMCID: PMC4924854.

4: Kim Y, Miyashita M, Miyagawa H. Early signaling events induced by the peptide elicitor PIP-1 necessary for acetosyringone accumulation in tobacco cells. Biosci Biotechnol Biochem. 2016 Jun;80(6):1054-7. doi: 10.1080/09168451.2016.1151342. Epub 2016 Feb 29. PubMed PMID: 26924306.

5: Hao S, Chen K, Cao L, Zhu X, Luo G, Zhang S, Chen J. Separation of high-purity syringol and acetosyringone from rice straw-derived bio-oil by combining the basification-acidification process and column chromatography. Electrophoresis. 2016 Oct;37(19):2522-2530. doi: 10.1002/elps.201600126. Epub 2016 Aug 2. PubMed PMID: 27482944.

6: Baker CJ, Mock NM, Whitaker BD, Roberts DP, Rice CP, Deahl KL, Aver'yanov AA. Involvement of acetosyringone in plant-pathogen recognition. Biochem Biophys Res Commun. 2005 Mar 4;328(1):130-6. PubMed PMID: 15670760.

7: Shaw CH, Ashby AM, Brown A, Royal C, Loake GJ, Shaw CH. virA and virG are the Ti-plasmid functions required for chemotaxis of Agrobacterium tumefaciens towards acetosyringone. Mol Microbiol. 1988 May;2(3):413-7. PubMed PMID: 3398775.

8: Hua SS. Inhibitory effect of acetosyringone on two aflatoxin biosynthetic genes. Lett Appl Microbiol. 2001 Apr;32(4):278-81. PubMed PMID: 11298941.

9: Fortin C, Nester EW, Dion P. Growth inhibition and loss of virulence in cultures of Agrobacterium tumefaciens treated with acetosyringone. J Bacteriol. 1992 Sep;174(17):5676-85. PubMed PMID: 1512200; PubMed Central PMCID: PMC206515.

10: Ankenbauer RG, Best EA, Palanca CA, Nester EW. Mutants of the Agrobacterium tumefaciens virA gene exhibiting acetosyringone-independent expression of the vir regulon. Mol Plant Microbe Interact. 1991 Jul-Aug;4(4):400-6. PubMed PMID: 1799700.

11: Harighi B. Genetic evidence for CheB- and CheR-dependent chemotaxis system in A. tumefaciens toward acetosyringone. Microbiol Res. 2009;164(6):634-41. doi: 10.1016/j.micres.2008.11.001. Epub 2009 Feb 23. PubMed PMID: 19231145.

12: Flores-Gómez E, Gómez-Silva L, Ruiz-Medrano R, Xoconostle-Cázeres B. Role of acetosyringone in the accumulation of a set of RNAs in the arbuscular mycorrhiza fungus Glomus intraradices. Int Microbiol. 2008 Dec;11(4):275-82. PubMed PMID: 19204900.

13: Saha P, Blumwald E. Spike-dip transformation of Setaria viridis. Plant J. 2016 Apr;86(1):89-101. doi: 10.1111/tpj.13148. Epub 2016 Mar 30. PubMed PMID: 26932666.

14: Turk SC, van Lange RP, Regensburg-Tuïnk TJ, Hooykaas PJ. Localization of the VirA domain involved in acetosyringone-mediated vir gene induction in Agrobacterium tumefaciens. Plant Mol Biol. 1994 Aug;25(5):899-907. PubMed PMID: 8075405.

15: Lipp João KH, Brown TA. Enhanced transformation of tomato co-cultivated with Agrobacterium tumefaciens C58C1Rif(r)::pGSFR1161 in the presence of acetosyringone. Plant Cell Rep. 1993 May;12(7-8):422-5. doi: 10.1007/BF00234705. PubMed PMID: 24197345.

16: Blount JW, Masoud S, Sumner LW, Huhman D, Dixon RA. Over-expression of cinnamate 4-hydroxylase leads to increased accumulation of acetosyringone in elicited tobacco cell-suspension cultures. Planta. 2002 Apr;214(6):902-10. Epub 2001 Dec 11. PubMed PMID: 11941467.

17: Banta LM, Joerger RD, Howitz VR, Campbell AM, Binns AN. Glu-255 outside the predicted ChvE binding site in VirA is crucial for sugar enhancement of acetosyringone perception by Agrobacterium tumefaciens. J Bacteriol. 1994 Jun;176(11):3242-9. PubMed PMID: 8195079; PubMed Central PMCID: PMC205494.

18: Lai EM, Shih HW, Wen SR, Cheng MW, Hwang HH, Chiu SH. Proteomic analysis of Agrobacterium tumefaciens response to the Vir gene inducer acetosyringone. Proteomics. 2006 Jul;6(14):4130-6. PubMed PMID: 16791832.

19: Harighi B. Role of CheY1 and CheY2 in the chemotaxis of A. tumefaciens toward acetosyringone. Curr Microbiol. 2008 Jun;56(6):547-52. doi: 10.1007/s00284-008-9120-1. Epub 2008 Mar 11. PubMed PMID: 18330636.

20: Sheikholeslam SN, Weeks DP. Acetosyringone promotes high efficiency transformation of Arabidopsis thaliana explants by Agrobacterium tumefaciens. Plant Mol Biol. 1987 Jul;8(4):291-8. doi: 10.1007/BF00021308. PubMed PMID: 24301191.