NS-6784

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530940

CAS#: 677723-97-6

Description: NS-6784 is discontinued. Customer who is interested in this product may contact DanPET AB (website www.danpet.eu).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-03. Prices are subject to change without notice.

NS-6784 is discontinued.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 530940
Name: NS-6784
CAS#: 677723-97-6
Chemical Formula: C15H18N4O
Exact Mass: 270.1481
Molecular Weight: 270.336
Elemental Analysis: C, 66.64; H, 6.71; N, 20.73; O, 5.92


Synonym: NS-6784; NS 6784; NS6784.

IUPAC/Chemical Name: 4-(5-Phenyl-1,3,4-oxadiazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane

InChi Key: NFQNAHNFWFCCMJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H18N4O/c1-2-4-12(5-3-1)14-16-17-15(20-14)19-11-10-18-8-6-13(19)7-9-18/h1-5,13H,6-11H2

SMILES Code: N1(CC2)CCN(C3=NN=C(C4=CC=CC=C4)O3)C2CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ween H, Thorin-Hagene K, Andersen E, Grønlien JH, Lee CH, Gopalakrishnan M,
Malysz J. Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32
neuroblastoma cells. Neurochem Int. 2010 Oct;57(3):269-77. doi:
10.1016/j.neuint.2010.06.005. Epub 2010 Jun 15. PubMed PMID: 20558224.

2: Briggs CA, Grønlien JH, Curzon P, Timmermann DB, Ween H, Thorin-Hagene K, Kerr
P, Anderson DJ, Malysz J, Dyhring T, Olsen GM, Peters D, Bunnelle WH,
Gopalakrishnan M. Role of channel activation in cognitive enhancement mediated by
alpha7 nicotinic acetylcholine receptors. Br J Pharmacol. 2009
Nov;158(6):1486-94. doi: 10.1111/j.1476-5381.2009.00426.x. Epub 2009 Oct 20.
PubMed PMID: 19845675; PubMed Central PMCID: PMC2795215.

3: Gopalakrishnan SM, Philip BM, Gronlien JH, Malysz J, Anderson DJ,
Gopalakrishnan M, Warrior U, Burns DJ. Functional characterization and
high-throughput screening of positive allosteric modulators of α7 nicotinic
acetylcholine receptors in IMR-32 neuroblastoma cells. Assay Drug Dev Technol.
2011 Dec;9(6):635-45. doi: 10.1089/adt.2010.0319. Epub 2011 Feb 10. PubMed PMID:
21309712.

4: Grønlien JH, Ween H, Thorin-Hagene K, Cassar S, Li J, Briggs CA,
Gopalakrishnan M, Malysz J. Importance of M2-M3 loop in governing properties of
genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A
chimera. Eur J Pharmacol. 2010 Nov 25;647(1-3):37-47. doi:
10.1016/j.ejphar.2010.08.027. Epub 2010 Sep 9. PubMed PMID: 20816816.