NSC156529
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MedKoo CAT#: 561470

CAS#: 41134-88-7

Description: NSC156529 downregulates AKT1 signaling, efficiently decreasing the proliferation of human cancer cells in vitro, and substantially inhibiting the growth of prostate tumor xenografts in vivo.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 250 2 Weeks
25mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC156529 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561470
Name: NSC156529
CAS#: 41134-88-7
Chemical Formula: C28H21ClS2
Exact Mass:
Molecular Weight: 457.05
Elemental Analysis: C, 73.58; H, 4.63; Cl, 7.76; S, 14.03


Synonym: NSC156529; NSC-156529; NSC 156529;

IUPAC/Chemical Name: 6-Methyl-2-phenyl-10-phenylsulfanyl-1H-anthra[1,9-bc]thiophenium chloride

InChi Key: KLQVNXJBZZWIIV-UHFFFAOYSA-M

InChi Code: InChI=1S/C28H21S2.ClH/c1-19-22-14-8-16-25(29-20-10-4-2-5-11-20)27(22)24-18-30(21-12-6-3-7-13-21)26-17-9-15-23(19)28(24)26;/h2-17H,18H2,1H3;1H/q+1;/p-1

SMILES Code: CC1=C2C=CC=C(SC3=CC=CC=C3)C2=C4C5=C1C=CC=C5[S+](C6=CC=CC=C6)C4.[Cl-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Mäemets-Allas K, Belitškin D, Jaks V. The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells. Biochem Biophys Res Commun. 2016 May 20;474(1):118-125. doi: 10.1016/j.bbrc.2016.04.082. Epub 2016 Apr 19. PubMed PMID: 27103434.

2: Mäemets-Allas K, Viil J, Jaks V. A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo. Mol Cancer Ther. 2015 Nov;14(11):2486-96. doi: 10.1158/1535-7163.MCT-15-0281. Epub 2015 Aug 20. PubMed PMID: 26294745.