WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571316
Description: AB-182 is an aziridine derivative and antitumor agent.
MedKoo Cat#: 571316
Chemical Formula: C11H22N3O4P
Exact Mass: 291.1348
Molecular Weight: 291.29
Elemental Analysis: C, 45.36; H, 7.61; N, 14.43; O, 21.97; P, 10.63
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: AB-182; AB 182; AB182
IUPAC/Chemical Name: Carbamic acid, ((bis(2,2-dimethyl-1-aziridinyl)phosphinyl)oxy)-, ethyl ester
InChi Key: AFKSFHAZSHQZMC-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H22N3O4P/c1-6-17-9(15)12-18-19(16,13-7-10(13,2)3)14-8-11(14,4)5/h6-8H2,1-5H3,(H,12,15)
SMILES Code: O=C(OCC)NOP(N1C(C)(C)C1)(N2C(C)(C)C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 291.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1653-6. PubMed PMID: 536272.
2: Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1677-80. PubMed PMID: 536276.