AB-182

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571316

CAS#: 54805-58-2

Description: AB-182 is an aziridine derivative and antitumor agent.


Price and Availability

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Price

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AB-182 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571316
Name: AB-182
CAS#: 54805-58-2
Chemical Formula: C11H22N3O4P
Exact Mass: 291.1348
Molecular Weight: 291.29
Elemental Analysis: C, 45.36; H, 7.61; N, 14.43; O, 21.97; P, 10.63


Synonym: AB-182; AB 182; AB182

IUPAC/Chemical Name: Carbamic acid, ((bis(2,2-dimethyl-1-aziridinyl)phosphinyl)oxy)-, ethyl ester

InChi Key: AFKSFHAZSHQZMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H22N3O4P/c1-6-17-9(15)12-18-19(16,13-7-10(13,2)3)14-8-11(14,4)5/h6-8H2,1-5H3,(H,12,15)

SMILES Code: O=C(OCC)NOP(N1C(C)(C)C1)(N2C(C)(C)C2)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Bardos TJ, Dunn JA, Perlman ME. Chemical mechanism of the radiation potentiating effects of 2,2-dimethylaziridine-type antitumor agents. Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1653-6. PubMed PMID: 536272.

2: Wodinsky I, Clement J, Swiniarski J, Skura A. Combined therapy with an aziridine derivative NSC 200724 (AB182) and radiation on an experimental leukemia. Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1677-80. PubMed PMID: 536276.