WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558269
CAS#: 1448189-80-7 (HCl)
Description: MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader. MDK7526 has CAS#1448297-52-6, its HCl salt has CAS#1448189-80-7. MDK7526 is potential useful for the targeted degradation of the androgen receptor. MDK7526 binds androgen receptor such that androgen receptor is placed in proximity to the ubiquitin ligase to effect degrdn. (and inhibition) of androgen receptor.
MedKoo Cat#: 558269
Name: MDK7526 HCl
CAS#: 1448189-80-7 (HCl)
Chemical Formula: C22H31ClN4O3S
Exact Mass: 466.1805
Molecular Weight: 467.025
Elemental Analysis: C, 56.58; H, 6.69; Cl, 7.59; N, 12.00; O, 10.28; S, 6.86
Related CAS #: 1448297-52-6 (free base) 1448189-80-7 (HCl)
Synonym: Protein degrader 1 hydrochloride; MDK7526 HCl; MDK7526; MDK-7526; MDK 7526; VHL Ligand 1; ULM-1; VH032 desacetyl Hydrochloride; VH032 amine HCl; Degradation Inducing Moiety A;
IUPAC/Chemical Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
InChi Key: JYRTWGCWUBURGU-MSSRUXLCSA-N
InChi Code: InChI=1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17+,19-;/m1./s1
SMILES Code: O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl
Preparation of thioxoimidazolidinone compounds and methods for the targeted degradation of the androgen receptor
By: Jin, Meizhong; Crew, Andrew P.; Dong, Hanqing; Wang, Jing; Siu, Kam; Ferraro, Caterina; Chen, Xin; Qian, Yimin
Assignee: Arvinas, Inc., USA
WO 2016118666
