MDK7526 HCl
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MedKoo CAT#: 558269

CAS#: 1448189-80-7 (HCl)

Description: MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader. MDK7526 has CAS#1448297-52-6, its HCl salt has CAS#1448189-80-7. MDK7526 is potential useful for the targeted degradation of the androgen receptor. MDK7526 binds androgen receptor such that androgen receptor is placed in proximity to the ubiquitin ligase to effect degrdn. (and inhibition) of androgen receptor.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1050 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2150 2 Weeks
1g USD 2950 2 Weeks
2g USD 4950 2 Weeks
5g USD 7650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

MDK7526 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558269
Name: MDK7526 HCl
CAS#: 1448189-80-7 (HCl)
Chemical Formula: C22H31ClN4O3S
Exact Mass: 466.1805
Molecular Weight: 467.025
Elemental Analysis: C, 56.58; H, 6.69; Cl, 7.59; N, 12.00; O, 10.28; S, 6.86


Related CAS #: 1448297-52-6 (free base)   1448189-80-7 (HCl)    

Synonym: Protein degrader 1 hydrochloride; MDK7526 HCl; MDK7526; MDK-7526; MDK 7526; VHL Ligand 1; ULM-1; VH032 desacetyl Hydrochloride; VH032 amine HCl; Degradation Inducing Moiety A;

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

InChi Key: JYRTWGCWUBURGU-MSSRUXLCSA-N

InChi Code: InChI=1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17+,19-;/m1./s1

SMILES Code: O=C([C@H]1N(C([C@@H](N)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

Preparation of thioxoimidazolidinone compounds and methods for the targeted degradation of the androgen receptor
By: Jin, Meizhong; Crew, Andrew P.; Dong, Hanqing; Wang, Jing; Siu, Kam; Ferraro, Caterina; Chen, Xin; Qian, Yimin
Assignee: Arvinas, Inc., USA
WO 2016118666