WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571304
CAS#: 14984-65-7
Description: AB 163 is a TEPA analogue that has been tested for use in radiation therapy for patients with esophageal carcinoma; adenocarcinomas of the gastrointestinal tract; squamous carcinoma of the cervix; and adenocarcinoma of the ovary. The drug is proposed to phosphorylate X ray induced DNA strand damage, and prolongs time of the absence of disease in patients. There may side effects on the GI system and the central nervous system.
MedKoo Cat#: 571304
Name: AB 163
CAS#: 14984-65-7
Chemical Formula: C10H21N2O2P
Exact Mass: 232.1341
Molecular Weight: 232.2638
Elemental Analysis: C, 51.71; H, 9.11; N, 12.06; O, 13.78; P, 13.34
This product is not in stock, which may be available by custom synthesis.
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Synonym: AB 163; AB163; AB-163; NSC 108878; NSC-108878; NSC108878
IUPAC/Chemical Name: Bis(2,2-dimethyl-1-aziridinyl)phosphinic acid ethyl ester
InChi Key: SOYAWOSQURUWHG-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H21N2O2P/c1-6-14-15(13,11-7-9(11,2)3)12-8-10(12,4)5/h6-8H2,1-5H3
SMILES Code: O=P(N1C(C)(C)C1)(N2C(C)(C)C2)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 232.2638 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wampler GL, Wassum JA, Belgrad R. Radiation potentiating effect of ethyl bis(2,2-dimethyl-1-aziridinyl) phosphinate (AB-163). Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1681-3. PubMed PMID: 536277.
2: Belgrad R, Wampler GL. A pilot study with ethyl bis (2,2-dimethyl-1-aziridinyl) phosphinate (AB-163) and radiation therapy. Int J Radiat Oncol Biol Phys. 1982 Jul;8(7):1219-23. PubMed PMID: 6811518.
3: Munson AE, Babbitt H, Chmielewicz ZF, Bardos TJ, Ambrus JL. Studies on the chemistry, antitumor activity, and pharmacology of ethyl di-(2,2-dimethyl)ethylenamido phosphate (AB-163). J Surg Oncol. 1969;1(2):167-80. PubMed PMID: 5406362.
4: Sreekumar E, Premraj A, Arathy DS, Rasool TJ. Identification, sequence characterization, and analysis of expression profiles of three novel CC chemokines from domestic duck (Anas platyrhynchos). Immunogenetics. 2005 Jun;57(5):364-73. Epub 2005 Apr 20. PubMed PMID: 15841394.
5: Wampler GL, Kuperminc M, Regelson W. Phase I study of ethylbis(2,2-dimethyl-1-aziridinyl) phosphinate (AB-163). Cancer Chemother Pharmacol. 1980;4(1):49-52. PubMed PMID: 7363402.
6: MacDiarmid JE, Rose WC, Biddle WC, Perlman ME, Breiner RG, Ambrus JL, Bardos TJ. Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents. J Med Chem. 1985 Nov;28(11):1685-91. PubMed PMID: 4067995.
7: Dunn JA, Bardos TJ. Comparative chemical and biological studies of four prototype phosphoraziridine antineoplastic agents. Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):885-92. PubMed PMID: 2009083.
