BIX
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MedKoo CAT#: 561442

CAS#: 101714-41-4

Description: BIX, also known as BiP Inducer X, is a BiP (Hsp70-5) ER chaperone inducer. BIX induces BiP expression in vitro and in vivo. Protects against ER-stress induced cell death in neuronal and retinal cell lines.

Chemical Structure

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BIX
CAS# 101714-41-4
Instruction

Theoretical Analysis

MedKoo Cat#: 561442
Name: BIX
CAS#: 101714-41-4
Chemical Formula: C9H7NO3S
Exact Mass: 209.01
Molecular Weight: 209.220
Elemental Analysis: C, 51.67; H, 3.37; N, 6.69; O, 22.94; S, 15.32

Price and Availability

Size Price Availability Quantity
5mg USD 385 2 weeks
25mg USD 750 2 weeks
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Synonym: BIX; BiP Inducer X,

IUPAC/Chemical Name: 2-(3,4-Dihydroxyphenyl)-2-oxoethyl thiocyanate

InChi Key: SVFLBLCWKKQKDW-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H7NO3S/c10-5-14-4-9(13)6-1-2-7(11)8(12)3-6/h1-3,11-12H,4H2

SMILES Code: O=C(C1=CC=C(O)C(O)=C1)CSC#N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 209.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M. A molecular chaperone inducer protects neurons from ER stress. Cell Death Differ. 2008 Feb;15(2):364-75. Epub 2007 Nov 30. PubMed PMID: 18049481.

2: Oida Y, Izuta H, Oyagi A, Shimazawa M, Kudo T, Imaizumi K, Hara H. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res. 2008 May 7;1208:217-24. doi: 10.1016/j.brainres.2008.02.068. Epub 2008 Mar 4. PubMed PMID: 18395193.

3: Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, Araie M, Hara H. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):334-44. doi: 10.1167/iovs.08-2123. Epub 2008 Aug 29. PubMed PMID: 18757512.