S-40503

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530915

CAS#: 404920-28-1

Description: S-40503 is an investigational selective androgen receptor modulator (SARM) developed by the Japanese company Kaken Pharmaceuticals, which was developed for the treatment of osteoporosis. SARMs are a new class of drugs which produce tissue-specific anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in other tissues such as in the prostate gland, thus avoiding side effects such as benign prostatic hypertrophy which can occur following treatment with unselective androgens like testosterone or anabolic steroids.


Chemical Structure

img
S-40503
CAS# 404920-28-1

Theoretical Analysis

MedKoo Cat#: 530915
Name: S-40503
CAS#: 404920-28-1
Chemical Formula: C15H23N3O3
Exact Mass: 293.1739
Molecular Weight: 293.367
Elemental Analysis: C, 61.41; H, 7.90; N, 14.32; O, 16.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 1345011-36-0 (RR isomer)   404920-28-1    

Synonym: S-40503; S40503; S40503.

IUPAC/Chemical Name: 2-[4-(Dimethylamino)-6-nitro-1,2,3,4-tetrahydro-2-chinolinyl]-2-methyl-1-propanol

InChi Key: YNYAUBNZRZVNLX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H23N3O3/c1-15(2,9-19)14-8-13(17(3)4)11-7-10(18(20)21)5-6-12(11)16-14/h5-7,13-14,16,19H,8-9H2,1-4H3

SMILES Code: CC(C)(C1NC2=C(C=C([N+]([O-])=O)C=C2)C(N(C)C)C1)CO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 293.367 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell
Endocrinol. 2017 Jan 27. pii: S0303-7207(17)30053-9. doi:
10.1016/j.mce.2017.01.040. [Epub ahead of print] PubMed PMID: 28137616.

2: Kearbey JD, Gao W, Fisher SJ, Wu D, Miller DD, Dalton JT. Effects of selective
androgen receptor modulator (SARM) treatment in osteopenic female rats. Pharm
Res. 2009 Nov;26(11):2471-7. doi: 10.1007/s11095-009-9962-7. Epub 2009 Sep 1.
PubMed PMID: 19728047.

3: Thevis M, Beuck S, Thomas A, Kortner B, Kohler M, Rodchenkov G, Schänzer W.
Doping control analysis of emerging drugs in human plasma - identification of
GW501516, S-107, JTV-519, and S-40503. Rapid Commun Mass Spectrom. 2009
Apr;23(8):1139-46. doi: 10.1002/rcm.3987. PubMed PMID: 19280612.

4: Hanada K, Furuya K, Yamamoto N, Nejishima H, Ichikawa K, Nakamura T, Miyakawa
M, Amano S, Sumita Y, Oguro N. Bone anabolic effects of S-40503, a novel
nonsteroidal selective androgen receptor modulator (SARM), in rat models of
osteoporosis. Biol Pharm Bull. 2003 Nov;26(11):1563-9. PubMed PMID: 14600402.