Zatebradine HCl | CAS#91940-87-3 | bradycardic agent

Zatebradine HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561430

CAS#: 91940-87-3

Description: Zatebradine HCl is a bradycardic agent. It blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells.

Chemical Structure

Zatebradine HCl

CAS# 91940-87-3

Instruction

Theoretical Analysis

MedKoo Cat#: 561430
Name: Zatebradine HCl
CAS#: 91940-87-3
Chemical Formula: C26H37ClN2O5
Exact Mass: 0.00
Molecular Weight: 493.040
Elemental Analysis: C, 63.34; H, 7.56; Cl, 7.19; N, 5.68; O, 16.22

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 230
10mg	USD 390
25mg	USD 730
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Zatebradine HCl; Zatebradine Hydrochloride; UL-FS49; UL FS49; ULFS49;

IUPAC/Chemical Name: 3-[3-[2-(3,4-Dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride

InChi Key: ZRNKXJHEQKMWCH-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H

SMILES Code: O=C1CC2=CC(OC)=C(OC)C=C2CCN1CCCN(CCC3=CC=C(OC)C(OC)=C3)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 493.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bois P, Guinamard R, Chemaly AE, Faivre JF, Bescond J. Molecular regulation and pharmacology of pacemaker channels. Curr Pharm Des. 2007;13(23):2338-49. Review. PubMed PMID: 17692005.

2: Schipke JD, Büter I, Hohlfeld T, Schmitz-Spanke S, Gams E. [Selective I(f) channel inhibition: an alternative for treating coronary artery disease?]. Herz. 2006 Feb;31(1):55-74. Review. German. PubMed PMID: 16502273.

3: Cerbai E, Mugelli A. [The pacemaker current If: a novel pharmacological target for cardiologists]. Ital Heart J Suppl. 2005 Jul;6(7):413-9. Review. Italian. PubMed PMID: 16082824.

4: Berdeaux A, Colin P, Monnet X, Ghaleh B. [Heart rate and experimental myocardial ischaemia]. Therapie. 2004 Sep-Oct;59(5):507-10. Review. French. PubMed PMID: 15648302.

5: Yusuf S, Camm AJ. Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven? J Cardiovasc Pharmacol Ther. 2003 Jun;8(2):89-105. Review. PubMed PMID: 12808482.

6: De Clerck F, Van de Water A, D'Aubioul J, Lu HR, van Rossem K, Hermans A, Van Ammel K. In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: application to the preclinical cardiovascular safety pharmacology of a new chemical entity. Fundam Clin Pharmacol. 2002 Apr;16(2):125-40. Review. PubMed PMID: 12031065.

7: Schipke JD, Harasawa Y, Sugiura S, Alexander J Jr, Burkhoff D. Effect of a bradycardic agent on the isolated blood-perfused canine heart. Cardiovasc Drugs Ther. 1991 Apr;5(2):481-8. Review. PubMed PMID: 1854656.

8: Kobinger W, Lillie C. Specific bradycardic agents--a novel pharmacological class? Eur Heart J. 1987 Dec;8 Suppl L:7-15. Review. PubMed PMID: 2897916.

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Zatebradine HCl featured