KUNG38

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571302

CAS#: 1887033-00-2

Description: KUNG38 is a purine-based inhibitor of Grp94. Specifically, it is a Grp94-selective inhibitor isolated through probing of the exclusive binding region of S1 subpocket in Grp94.


Chemical Structure

img
KUNG38
CAS# 1887033-00-2

Theoretical Analysis

MedKoo Cat#: 571302
Name: KUNG38
CAS#: 1887033-00-2
Chemical Formula: C18H16Cl2N2O5
Exact Mass: 410.04
Molecular Weight: 411.240
Elemental Analysis: C, 52.57; H, 3.92; Cl, 17.24; N, 6.81; O, 19.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KUNG38; KUNG-38; KUNG 38

IUPAC/Chemical Name: methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate

InChi Key: HIYQDMHJUHUDDN-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H16Cl2N2O5/c1-26-18(25)16-11(17(20)13(24)8-12(16)23)3-5-15-21-6-7-22(15)9-10-2-4-14(19)27-10/h2,4,6-8,23-24H,3,5,9H2,1H3

SMILES Code: ClC1=CC=C(CN2C=CN=C2CCC3=C(C(OC)=O)C(O)=CC(O)=C3Cl)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Hsp90 proteins are responsible for the maturation and activation of more than 300 polypeptides into proteins; they also remature denatured proteins. These products are often involved in signaling pathways implicated in cancer transformation, and thus Hsp90 inhibition has emerged as a combinatorial attack against cancer via a single molecular target. More specifically, in the ER, the Hsp90 form present is Grp94. It matures and transports proteins for signaling and cellular adhesion, which eventually play a role in integrin maturation and cell polarity. This target could play an important role in hepatocellular carcinoma, multiple myeloma, rheumatoid arthritis, and glaucoma. Grp94 is essential during embryonic development and thus represents a nontoxic target that can be inhibited to treat these diseases.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 411.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Khandelwal A, Crowley VM, Blagg BSJ. Resorcinol-Based Grp94-Selective Inhibitors. ACS Medicinal Chemistry Letters. 2017 September 1. doi: 10.1021/acsmedchemlett.7b00193