Nefazodone HCl
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MedKoo CAT#: 540313

CAS#: 82752-99-6

Description: Nefazodone HCl is an inhibitor of 5-HT2 receptors, SERT, NET, and hERG K+ channels used to treat mood disorders. It decreases immobility time in the forced swim test.


Price and Availability

Size Price Shipping out time Quantity
200mg USD 590 2 Weeks
1g USD 265 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

Nefazodone HCl purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 540313
Name: Nefazodone HCl
CAS#: 82752-99-6
Chemical Formula: C25H33Cl2N5O2
Exact Mass: 505.2011
Molecular Weight: 506.47
Elemental Analysis: C, 59.29; H, 6.57; Cl, 14.00; N, 13.83; O, 6.32


Synonym: BMY 13754; BMY13754; BMY-13754; Dutonin; Nefazodone HCl; Rulivan; MJ 13754 1; MJ-13754-1; MJ137541

IUPAC/Chemical Name: 2-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride

InChi Key: DYCKFEBIOUQECE-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

SMILES Code: O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Owens MJ, Ieni JR, Knight DL, Winders K, Nemeroff CB. The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life Sci. 1995;57(24):PL373-80. PubMed PMID: 7475971.

2: Sreenivas Rao D, Geetha S, Srinivasu MK, Om Reddy G. LC determination and purity evaluation of nefazodone HCl in bulk drug and pharmaceutical formulations. J Pharm Biomed Anal. 2001 Nov;26(4):629-36. PubMed PMID: 11516915.

3: Dursun SM, Bird D, Ronson KE. Nefazodone treatment of dysthymic disorder an open, long-term, prospective pilot study. Prog Neuropsychopharmacol Biol Psychiatry. 2002 May;26(4):671-6. PubMed PMID: 12188098.

4: Marathe PH, Salazar DE, Greene DS, Brennan J, Shukla UA, Barbhaiya RH. Absorption and presystemic metabolism of nefazodone administered at different regions in the gastrointestinal tract of humans. Pharm Res. 1995 Nov;12(11):1716-21. PubMed PMID: 8592675.