Alazopeptin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571285

CAS#: 1397-84-8

Description: Alazopeptin is an antitumor antibiotic. It has trypanocidal properties.

Chemical Structure

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Alazopeptin
CAS# 1397-84-8
Instruction

Theoretical Analysis

MedKoo Cat#: 571285
Name: Alazopeptin
CAS#: 1397-84-8
Chemical Formula: C15H20N6O5
Exact Mass: 364.15
Molecular Weight: 364.360
Elemental Analysis: C, 49.45; H, 5.53; N, 23.07; O, 21.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Alazopeptin; AA223 Lederle; AA 223 Lederle; AA-223 Lederle

IUPAC/Chemical Name: Allyl-(6-diazo-5-oxo)-norleucyl-(6-diazo-5-oxo)-norleucine

InChi Key: LKVFXQOHKMMISY-STQMWFEESA-N

InChi Code: InChI=1S/C15H20N6O5/c1-2-7-21(13(15(25)26)6-4-11(23)9-20-18)14(24)12(16)5-3-10(22)8-19-17/h2,8-9,12-13H,1,3-7,16H2,(H,25,26)/t12-,13-/m0/s1

SMILES Code: O=C(O)[C@H](CCC(C=[N+]=[N-])=O)N(CC=C)C([C@H](CCC(C=[N+]=[N-])=O)N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 364.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Patterson EL, Johnson BL, DeVoe SE, Bohonos N. Structure of the antitumor antibiotic alazopeptin. Antimicrob Agents Chemother (Bethesda). 1965;5:115-8. PubMed PMID: 5883414.

2: DE VOE SE, RIGLER NE, SHAY AJ, MARTIN JH, BOYD TC, BACKUS EJ, MOWAT JH, BOHONOS N. Alazopeptin; production, isolation, and chemical characteristics. Antibiot Annu. 1956-1957:730-5. PubMed PMID: 13425456.

3: Ishiyama A, Otoguro K, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Ichimura M, Yamada H, Omura S. In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin. J Antibiot (Tokyo). 2008 Oct;61(10):627-32. doi: 10.1038/ja.2008.83. PubMed PMID: 19168977.

4: THIERSCH JB. Effect of alazopeptin on litter and fetus of the rat in utero. Proc Soc Exp Biol Med. 1958 Apr;97(4):888-9. PubMed PMID: 13554513.

5: Hata T, Umezawa I, Iwai Y, Katagiri M, Awaya J. Studies on the antitumor activity of an alazopeptin isolated from a new strain of Streptomyces. J Antibiot (Tokyo). 1973 Mar;26(3):181-3. PubMed PMID: 4205875.