WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561422
Description: Carboxy-PTIO is a NO scavenger. Streptozotocin (STZ) induced diabetes (type I) in rats is preventable using a simultaneous equimolar injection of carboxy-PTIO.
MedKoo Cat#: 561422
Chemical Formula: C14H16KN2O4
Exact Mass: 315.0747
Molecular Weight: 315.39
Elemental Analysis: C, 53.32; H, 5.11; K, 12.40; N, 8.88; O, 20.29
Synonym: cPTIO; Carboxy-PTIO; Carboxy PTIO; CarboxyPTIO;
IUPAC/Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt
InChi Key: VYEUQMVIGXFZQU-UHFFFAOYSA-M
InChi Code: InChI=1S/C14H17N2O4.K/c1-13(2)14(3,4)16(20)11(15(13)19)9-5-7-10(8-6-9)12(17)18;/h5-8H,1-4H3,(H,17,18);/q;+1/p-1
SMILES Code: [O]N1C(C)(C)C(C)(C)[N+]([O-])=C1C2=CC=C(C([O-])=O)C=C2.[K+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 315.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Lu C, Kavalier A, Lukyanov E, Gross SS. S-sulfhydration/desulfhydration and S-nitrosylation/denitrosylation: a common paradigm for gasotransmitter signaling by H2S and NO. Methods. 2013 Aug 1;62(2):177-81. doi: 10.1016/j.ymeth.2013.05.020. Epub 2013 Jun 27. Review. PubMed PMID: 23811297; PubMed Central PMCID: PMC3923419.
2: Van Dyke K, Jabbour N, Hoeldtke R, Van Dyke C, Van Dyke M. Oxidative/nitrosative stresses trigger type I diabetes: preventable in streptozotocin rats and detectable in human disease. Ann N Y Acad Sci. 2010 Aug;1203:138-45. doi: 10.1111/j.1749-6632.2010.05563.x. Review. PubMed PMID: 20716296.
3: Mori T, Cowley AW Jr, Ito S. Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla. J Pharmacol Sci. 2006 Jan;100(1):2-8. Epub 2006 Jan 11. Review. PubMed PMID: 16404134.
4: Guimarães FS, Beijamini V, Moreira FA, Aguiar DC, de Lucca AC. Role of nitric oxide in brain regions related to defensive reactions. Neurosci Biobehav Rev. 2005;29(8):1313-22. Epub 2005 Aug 10. Review. PubMed PMID: 16095696.
5: Gibson A, Lilley E. Superoxide anions, free-radical scavengers, and nitrergic neurotransmission. Gen Pharmacol. 1997 Apr;28(4):489-93. Review. PubMed PMID: 9147013.
6: Maeda H, Akaike T, Yoshida M, Sato K, Noguchi Y. A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative, and its effects in pathophysiology and microbiology. Curr Top Microbiol Immunol. 1995;196:37-50. Review. PubMed PMID: 7543398.