ICL-CCIC-0019

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561410

CAS#: 936498-64-5

Description: ICL-CCIC-0019 is a choline kinase alpha (CHKA) inhibitor. ICL-CCIC-0019 decreases phosphocholine levels and the fraction of labeled choline in lipids, and induces G1 arrest, endoplasmic reticulum stress and apoptosis of a panel of 60 cancer cell lines.


Chemical Structure

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ICL-CCIC-0019
CAS# 936498-64-5

Theoretical Analysis

MedKoo Cat#: 561410
Name: ICL-CCIC-0019
CAS#: 936498-64-5
Chemical Formula: C26H44Br2N4
Exact Mass:
Molecular Weight: 572.47
Elemental Analysis: C, 54.55; H, 7.75; Br, 27.92; N, 9.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICL-CCIC-0019; ICL CCIC 0019; ICLCCIC0019;

IUPAC/Chemical Name: 1,1'-(1,12-Dodecanediyl)bis[4-(dimethylamino)pyridinium] dibromide

InChi Key: SRYRXSJEWKGQSC-UHFFFAOYSA-L

InChi Code: InChI=1S/C26H44N4.2BrH/c1-27(2)25-15-21-29(22-16-25)19-13-11-9-7-5-6-8-10-12-14-20-30-23-17-26(18-24-30)28(3)4;;/h15-18,21-24H,5-14,19-20H2,1-4H3;2*1H/q+2;;/p-2

SMILES Code: CN(C1=CC=[N+](CCCCCCCCCCCC[N+]2=CC=C(N(C)C)C=C2)C=C1)C.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 572.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Trousil S, Kaliszczak M, Schug Z, Nguyen QD, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, Aboagye EO. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016 Jun 14;7(24):37103-37120. doi: 10.18632/oncotarget.9466. PubMed PMID: 27206796; PubMed Central PMCID: PMC5095062.