Osthole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558254

CAS#: 484-12-8

Description: Osthole is a calcium channel blocker, found in plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthole regulates inflammatory mediator expression through modulating NF-kappaB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.


Chemical Structure

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Osthole
CAS# 484-12-8

Theoretical Analysis

MedKoo Cat#: 558254
Name: Osthole
CAS#: 484-12-8
Chemical Formula: C15H16O3
Exact Mass: 244.1099
Molecular Weight: 244.29
Elemental Analysis: C, 73.75; H, 6.60; O, 19.65

Price and Availability

Size Price Availability Quantity
500.0mg USD 210.0 2 Weeks
1.0g USD 360.0 2 Weeks
5.0g USD 730.0 2 Weeks
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Synonym: Osthole; Osthol; Ostole; Ostol;

IUPAC/Chemical Name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one

InChi Key: MBRLOUHOWLUMFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3

SMILES Code: O=C1C=CC2=C(O1)C(C/C=C(C)\C)=C(OC)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Costa CR, Amorim BR, de Magalhães P, De Luca Canto G, Acevedo AC, Guerra EN. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytother Res. 2016 Apr;30(4):519-31. doi: 10.1002/ptr.5568. Epub 2016 Jan 29. Review. PubMed PMID: 26822584.

2: An J, Yang H, Zhang Q, Liu C, Zhao J, Zhang L, Chen B. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation. Life Sci. 2016 Feb 15;147:46-58. doi: 10.1016/j.lfs.2016.01.024. Epub 2016 Jan 18. Review. PubMed PMID: 26796578.

3: Zhang ZR, Leung WN, Cheung HY, Chan CW. Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evid Based Complement Alternat Med. 2015;2015:919616. doi: 10.1155/2015/919616. Epub 2015 Jul 13. Review. PubMed PMID: 26246843; PubMed Central PMCID: PMC4515521.

4: Li YM, Jia M, Li HQ, Zhang ND, Wen X, Rahman K, Zhang QY, Qin LP. Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties. Am J Chin Med. 2015;43(5):835-77. doi: 10.1142/S0192415X15500500. Epub 2015 Aug 4. Review. PubMed PMID: 26243582.

5: Sarkhail P. Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: a review. J Ethnopharmacol. 2014 Oct 28;156:235-70. doi: 10.1016/j.jep.2014.08.034. Epub 2014 Sep 3. Review. PubMed PMID: 25193684.

6: Zhou ZW, Liu PX. [Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri]. Zhongguo Zhong Yao Za Zhi. 2005 Sep;30(17):1309-13. Review. Chinese. PubMed PMID: 16323535.

7: Okamoto T, Kobayashi T, Yoshida S. Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Curr Med Chem Anticancer Agents. 2005 Jan;5(1):47-51. Review. PubMed PMID: 15720260.

8: Wu L, Cheng SY, Wang Q, Chen YB. [Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer's disease]. Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):387-9. Review. Chinese. PubMed PMID: 15706882.

9: Lian Q. [Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson]. Zhong Yao Cai. 2003 Feb;26(2):141-4. Review. Chinese. PubMed PMID: 12971400.

10: Hoult JR, Payá M. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential. Gen Pharmacol. 1996 Jun;27(4):713-22. Review. PubMed PMID: 8853310.

11: Liu SX, Chiou GC. Effects of Chinese herbal products on mammalian retinal functions. J Ocul Pharmacol Ther. 1996 Fall;12(3):377-86. Review. PubMed PMID: 8875344.

Osthole

500.0mg / USD 210.0