WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558254
CAS#: 484-12-8
Description: Osthole is a calcium channel blocker, found in plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthole regulates inflammatory mediator expression through modulating NF-kappaB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.
MedKoo Cat#: 558254
Name: Osthole
CAS#: 484-12-8
Chemical Formula: C15H16O3
Exact Mass: 244.1099
Molecular Weight: 244.29
Elemental Analysis: C, 73.75; H, 6.60; O, 19.65
Synonym: Osthole; Osthol; Ostole; Ostol;
IUPAC/Chemical Name: 7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
InChi Key: MBRLOUHOWLUMFF-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
SMILES Code: O=C1C=CC2=C(O1)C(C/C=C(C)\C)=C(OC)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Costa CR, Amorim BR, de Magalhães P, De Luca Canto G, Acevedo AC, Guerra EN. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytother Res. 2016 Apr;30(4):519-31. doi: 10.1002/ptr.5568. Epub 2016 Jan 29. Review. PubMed PMID: 26822584.
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