UK-414,495

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561394

CAS#: 337962-93-3

Description: UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. UK-414,495 is a drug used for the treatment of female sexual arousal disorder.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

UK-414,495 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561394
Name: UK-414,495
CAS#: 337962-93-3
Chemical Formula: C16H25N3O3S
Exact Mass: 339.1617
Molecular Weight: 339.454
Elemental Analysis: C, 56.61; H, 7.42; N, 12.38; O, 14.14; S, 9.44


Synonym: UK-414,495; UK 414,495; UK414,495; UK-414495; UK 414495; UK414495

IUPAC/Chemical Name: (R)-2-({1-[(5-Ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl}methyl)valeric acid

InChi Key: FWXXCSISWQQOGS-LLVKDONJSA-N

InChi Code: InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1

SMILES Code: CCC[C@H](CC1(C(NC2=NN=C(CC)S2)=O)CCCC1)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Wayman CP, Baxter D, Turner L, Van Der Graaf PH, Naylor AM. UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit. Br J Pharmacol. 2010 May;160(1):51-9. doi: 10.1111/j.1476-5381.2010.00691.x. PubMed PMID: 20412068; PubMed Central PMCID: PMC2860206.