Nefopam HCl

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MedKoo CAT#: 329820

CAS#: 23327-57-3 (HCl)

Description: Nefopam is a centrally-acting non-opioid analgesic drug. It is widely used, mainly in European countries, for the relief of moderate to severe pain as an alternative to opioid analgesic drugs. Animal studies have shown that nefopam has a potentiating (analgesic-sparing) effect on morphine and other opioids by broadening the antinociceptive action of the opioid and possibly other mechanisms, generally lowering the dose requirements of both when they are used concomitantly.

Price and Availability

Size Price Shipping out time Quantity
10mg USD 175 2 Weeks
50mg USD 550 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

Nefopam HCl , purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received. bulk quantity is available via custom synthesis.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 329820
Name: Nefopam HCl
CAS#: 23327-57-3 (HCl)
Chemical Formula: C17H20ClNO
Exact Mass:
Molecular Weight: 289.803
Elemental Analysis: C, 70.46; H, 6.96; Cl, 12.23; N, 4.83; O, 5.52

Related CAS #: 13669-70-0 (free base)   23327-57-3 (HCl)    

Synonym: Fenazoxine hydrochloride; Lenipan; Leoplexamin; Nefopam HCl; Nefopam hydrochloride; Oxadol; Pallopikeron, Brand name Acupan.

IUPAC/Chemical Name: 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride


InChi Code: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information

Nefopam has additional action in the prevention of shivering, which may be a side effect of other drugs used in surgery. Nefopam was significantly more effective than aspirin as an analgesic in one clinical trial, although with a greater incidence of side effects such as sweating, dizziness and nausea, especially at higher doses. Nefopam is around a third to half the potency and slightly less effective as an analgesic compared to morphine, or oxycodone, but tends to produce fewer side effects, does not produce respiratory depression, and has much less abuse potential, and so is useful either as an alternative to opioids, or as an adjunctive treatment for use alongside opioid(s) or other analgesics. Nefopam is also used to treat severe hiccups.


1: Girard P, Chauvin M, Verleye M. Nefopam analgesia and its role in multimodal analgesia: A review of preclinical and clinical studies. Clin Exp Pharmacol Physiol. 2016 Jan;43(1):3-12. doi: 10.1111/1440-1681.12506. Review. PubMed PMID: 26475417.

2: Kim KH, Abdi S. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11. doi: 10.3344/kjp.2014.27.2.103. Epub 2014 Mar 28. Review. PubMed PMID: 24748937; PubMed Central PMCID: PMC3990817.

3: Kakkar M, Derry S, Moore RA, McQuay HJ. Single dose oral nefopam for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007442. doi: 10.1002/14651858.CD007442.pub2. Review. PubMed PMID: 19588431; PubMed Central PMCID: PMC4170989.

4: Evans MS, Lysakowski C, Tramèr MR. Nefopam for the prevention of postoperative pain: quantitative systematic review. Br J Anaesth. 2008 Nov;101(5):610-7. doi: 10.1093/bja/aen267. Epub 2008 Sep 15. Review. PubMed PMID: 18796441.

5: Tracqui A, Berthelon L, Ludes B. Fatal overdosage with nefopam (Acupan). J Anal Toxicol. 2002 May-Jun;26(4):239-43. Review. PubMed PMID: 12054367.

6: Bilotta F, Pietropaoli P, Rosa G. Nefopam for refractory postoperative hiccups. Anesth Analg. 2001 Nov;93(5):1358-60. Review. PubMed PMID: 11682430.

7: Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1980 Apr;19(4):249-67. Review. PubMed PMID: 6991238.