AA 193

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571280

CAS#: 107804-48-8

Description: AA 193 is a selective inhibitor of the presecretory reabsorption of uric acid.


Chemical Structure

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AA 193
CAS# 107804-48-8

Theoretical Analysis

MedKoo Cat#: 571280
Name: AA 193
CAS#: 107804-48-8
Chemical Formula: C16H10ClNO4
Exact Mass: 315.0298
Molecular Weight: 315.71
Elemental Analysis: C, 60.87; H, 3.19; Cl, 11.23; N, 4.44; O, 20.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AA 193; AA-193; AA193

IUPAC/Chemical Name: Furo(2,3-g)-1,2-benzisoxazole-7-carboxylic acid, 5-chloro-7,8-dihydro-3-phenyl-

InChi Key: RVKIPRIYUGLRFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H10ClNO4/c17-11-6-9-13(8-4-2-1-3-5-8)18-22-14(9)10-7-12(16(19)20)21-15(10)11/h1-6,12H,7H2,(H,19,20)

SMILES Code: O=C(C(O1)CC2=C1C(Cl)=CC3=C2ON=C3C4=CC=CC=C4)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 315.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yamada H, Kotaki H, Furitsu H, Sawada Y, Iga T. Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice. Biopharm Drug Dispos. 1999 Jul;20(5):271-6. PubMed PMID: 10594872.

2: Yamada H, Kotaki H, Itoh T, Sawada Y, Iga T. Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles. Eur J Pharmacol. 2000 Oct 6;406(1):45-8. PubMed PMID: 11011031.

3: Lim RW, Furukawa R, Fechheimer M. Evidence of intramolecular regulation of the Dictyostelium discoideum 34 000 Da F-actin-bundling protein. Biochemistry. 1999 Dec 7;38(49):16323-32. PubMed PMID: 10587457.

4: Dan T, Onuma E, Tanaka H, Koga H. A selective uricosuric action of AA-193 in rats. Comparison with its effect on PAH secretion in vivo and in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1991 May;343(5):532-7. PubMed PMID: 1881462.

5: Dan T, Koga H, Onuma E, Tanaka H, Sato H, Aoki B. The activity of AA-193, a new uricosuric agent, in animals. Adv Exp Med Biol. 1989;253A:301-8. PubMed PMID: 2624207.

6: Dan T, Yoneya T, Onoma M, Onuma E, Ozawa K. Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. Metabolism. 1994 Jan;43(1):123-8. PubMed PMID: 8289669.

7: Dan T, Tanaka H, Koga H. Mechanism of uricosuric action of AA-193 in DBA/2N mice. J Pharmacol Exp Ther. 1990 May;253(2):437-43. PubMed PMID: 2338641.

8: Dan T, Koga H. Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur J Pharmacol. 1990 Oct 23;187(3):303-12. PubMed PMID: 2073918.

9: Kurane I, West K, Tuazon CU, Zeng W, Ennis FA. Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones. J Clin Virol. 2003 May;27(1):38-43. PubMed PMID: 12727527.

10: Sato H, Dan T, Onuma E, Tanaka H, Aoki B, Koga H. Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1760-72. PubMed PMID: 1777929. H