AA 193

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571280

CAS#: 107804-48-8

Description: AA 193 is a selective inhibitor of the presecretory reabsorption of uric acid.


Price and Availability

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AA 193 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571280
Name: AA 193
CAS#: 107804-48-8
Chemical Formula: C16H10ClNO4
Exact Mass: 315.0298
Molecular Weight: 315.71
Elemental Analysis: C, 60.87; H, 3.19; Cl, 11.23; N, 4.44; O, 20.27


Synonym: AA 193; AA-193; AA193

IUPAC/Chemical Name: Furo(2,3-g)-1,2-benzisoxazole-7-carboxylic acid, 5-chloro-7,8-dihydro-3-phenyl-

InChi Key: RVKIPRIYUGLRFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H10ClNO4/c17-11-6-9-13(8-4-2-1-3-5-8)18-22-14(9)10-7-12(16(19)20)21-15(10)11/h1-6,12H,7H2,(H,19,20)

SMILES Code: O=C(C(O1)CC2=C1C(Cl)=CC3=C2ON=C3C4=CC=CC=C4)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yamada H, Kotaki H, Furitsu H, Sawada Y, Iga T. Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice. Biopharm Drug Dispos. 1999 Jul;20(5):271-6. PubMed PMID: 10594872.

2: Yamada H, Kotaki H, Itoh T, Sawada Y, Iga T. Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles. Eur J Pharmacol. 2000 Oct 6;406(1):45-8. PubMed PMID: 11011031.

3: Lim RW, Furukawa R, Fechheimer M. Evidence of intramolecular regulation of the Dictyostelium discoideum 34 000 Da F-actin-bundling protein. Biochemistry. 1999 Dec 7;38(49):16323-32. PubMed PMID: 10587457.

4: Dan T, Onuma E, Tanaka H, Koga H. A selective uricosuric action of AA-193 in rats. Comparison with its effect on PAH secretion in vivo and in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1991 May;343(5):532-7. PubMed PMID: 1881462.

5: Dan T, Koga H, Onuma E, Tanaka H, Sato H, Aoki B. The activity of AA-193, a new uricosuric agent, in animals. Adv Exp Med Biol. 1989;253A:301-8. PubMed PMID: 2624207.

6: Dan T, Yoneya T, Onoma M, Onuma E, Ozawa K. Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model. Metabolism. 1994 Jan;43(1):123-8. PubMed PMID: 8289669.

7: Dan T, Tanaka H, Koga H. Mechanism of uricosuric action of AA-193 in DBA/2N mice. J Pharmacol Exp Ther. 1990 May;253(2):437-43. PubMed PMID: 2338641.

8: Dan T, Koga H. Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur J Pharmacol. 1990 Oct 23;187(3):303-12. PubMed PMID: 2073918.

9: Kurane I, West K, Tuazon CU, Zeng W, Ennis FA. Definition of two new epitopes on human immunodeficiency virus type 1 gag protein recognized by human CD8+ cytotoxic T lymphocyte clones. J Clin Virol. 2003 May;27(1):38-43. PubMed PMID: 12727527.

10: Sato H, Dan T, Onuma E, Tanaka H, Aoki B, Koga H. Studies on uricosuric diuretics. II. Substituted 7,8-dihydrofuro[2,3-g]-1,2-benzisoxazole-7-carboxylic acids and 7,8-dihydrofuro[2,3-g]benzoxazole-7-carboxylic acids. Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1760-72. PubMed PMID: 1777929. H