HBX 19,818

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571254

CAS#: NONE

Description: HBX 19,818 is a selective and irreversible USP7 inhibitor. HBX 19,818 has an IC50 of 28 μM In vivo activity for this compound has not yet been described.

Chemical Structure

img
HBX 19,818
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 571254
Name: HBX 19,818
CAS#: NONE
Chemical Formula: C25H28ClN3O
Exact Mass: 421.19
Molecular Weight: 421.970
Elemental Analysis: C, 71.16; H, 6.69; Cl, 8.40; N, 9.96; O, 3.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: HBX 19,818; HBX-41,818; HBX41,818; HBX 41818; HBX-41818; HBX41818

IUPAC/Chemical Name: N-(3-(benzyl(methyl)amino)propyl)-9-chloro-5,6,7,8-tetrahydroacridine-2-carboxamide

InChi Key: ZCALMLVWZSQGGR-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28ClN3O/c1-29(17-18-8-3-2-4-9-18)15-7-14-27-25(30)19-12-13-23-21(16-19)24(26)20-10-5-6-11-22(20)28-23/h2-4,8-9,12-13,16H,5-7,10-11,14-15,17H2,1H3,(H,27,30)

SMILES Code: O=C(C1=CC=C(N=C(CCCC2)C2=C3Cl)C3=C1)N([H])CCCN(C)CC4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Ubiquitin specific protease 7 (USP7) supports cancer by positively affecting tumor growth and negatively affecting the patient’s immune response to tumors. USP7 inhibitors thus are an avenue of interest in potential cancer treatment. USP7 plays an important role in antagonizing p53 functions through multiple mechanisms. p53 is a critical tumor suppressor, and mutations in p53 are found in more than 50% of human cancers.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 421.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Wu J, Kumar S, Wang F, Wang H, Chen L, Arsenault P, Mattern M, Weinstock J. Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2017 Aug 18. doi: 10.1021/acs.jmedchem.7b00498. [Epub ahead of print] PubMed PMID: 28768102.