A-49816 hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571252

CAS#: 78235-46-8

Description: A-49816 hydrochloride is a diuretic.

Chemical Structure

A-49816 hydrochloride
CAS# 78235-46-8

Theoretical Analysis

MedKoo Cat#: 571252
Name: A-49816 hydrochloride
CAS#: 78235-46-8
Chemical Formula: C18H18Cl3NO5
Exact Mass: 433.0251
Molecular Weight: 434.69
Elemental Analysis: C, 49.74; H, 4.17; Cl, 24.47; N, 3.22; O, 18.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A-49816 hydrochloride; A49816 hydrochloride; A 49816 hydrochloride; A-49816 HCl

IUPAC/Chemical Name: Acetic acid, (4-(3-(aminomethyl)-4-hydroxybenzoyl)-2,3-dichlorophenoxy)-, ethyl ester, hydrochloride


InChi Code: InChI=1S/C18H17Cl2NO5.ClH/c1-2-25-15(23)9-26-14-6-4-12(16(19)17(14)20)18(24)10-3-5-13(22)11(7-10)8-21;/h3-7,22H,2,8-9,21H2,1H3;1H

SMILES Code: O=C(OCC)COC1=CC=C(C(C2=CC=C(O)C(CN)=C2)=O)C(Cl)=C1Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 434.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Luther RR, Ringham GL, Steinberg FJ, Patterson KJ, Jordan DC, Rollins DE, Tolman KG. Pharmacologic effects of A-49816, a new high-ceiling diuretic. J Clin Pharmacol. 1987 Oct;27(10):794-801. PubMed PMID: 3323256.

2: Tolman KG, Gray PD, el Masry S, Luther RR, Janicki RS. Toxicity of uricosuric diuretics in rat hepatocyte culture. Biochem Pharmacol. 1989 Apr 1;38(7):1181-4. PubMed PMID: 2706015.