Melitracen HCl
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MedKoo CAT#: 540284

CAS#: 10563-70-9

Description: Melitracen HCl is a potential dopamine D1/2 receptor antagonist used to treat depression. It is often co-administered with flupenthixol as a treatment for trigeminal neuralgia. It does not effect cardiovascular function.

Chemical Structure

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Melitracen HCl
CAS# 10563-70-9
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 540284
Name: Melitracen HCl
CAS#: 10563-70-9
Chemical Formula: C21H26ClN
Exact Mass: 327.18
Molecular Weight: 327.896
Elemental Analysis: C, 76.92; H, 7.99; Cl, 10.81; N, 4.27

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
2g USD 400 2 Weeks
5g USD 750 2 Weeks
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Synonym: N 7001; N7001; N-7001; Melitracen HCl

IUPAC/Chemical Name: 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride

InChi Key: RADLXCPDUXFGFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25N.ClH/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21;/h5-8,10-14H,9,15H2,1-4H3;1H

SMILES Code: CC(C1=C/2C=CC=C1)(C)C3=CC=CC=C3C2=C/CCN(C)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 82.5 251.60
Ethanol 65.0 198.23
Water 82.5 251.60

Preparing Stock Solutions

The following data is based on the product molecular weight 327.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Thoma K, von Stein C. [The effect of changing the association properties of
psychopharmaceuticals in colloidal solutions on their liberation. 4. The effect
of chemical structure as well as environmental conditions on the elevation of
critical micelle formation concentration and reduction of micelle weight with
hydrotropic material]. Pharm Acta Helv. 1990;65(4):98-104. German. PubMed PMID:
2356194.