A 74932

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MedKoo CAT#: 571195

CAS#: 148201-60-9

Description: A 74932 is an inhibitor of DNA topoisomerases. It is a quinolone antibacterial agentand inhibitor of topoisomerase II enzyme. A-74932 possesses good activity in vivo against both systemic tumour and subcutaneously implanted murine solid tumours as well as human tumour xenografts.


Chemical Structure

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A 74932
CAS# 148201-60-9

Theoretical Analysis

MedKoo Cat#: 571195
Name: A 74932
CAS#: 148201-60-9
Chemical Formula: C25H26ClFN4O5
Exact Mass: 516.16
Molecular Weight: 516.950
Elemental Analysis: C, 58.09; H, 5.07; Cl, 6.86; F, 3.68; N, 10.84; O, 15.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A 74932; A-74932; A74932

IUPAC/Chemical Name: 6-((S)-2-((R)-2-aminopentanamido)pyrrolidin-1-yl)-5-fluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylic acid hydrochloride

InChi Key: UFBYBJURMXBKFU-VWJDFLIZSA-N

InChi Code: InChI=1S/C25H25FN4O5.ClH/c1-2-6-16(27)24(32)28-19-9-5-10-29(19)21-15(26)11-13-20-23(21)35-18-8-4-3-7-17(18)30(20)12-14(22(13)31)25(33)34;/h3-4,7-8,11-12,16,19H,2,5-6,9-10,27H2,1H3,(H,28,32)(H,33,34);1H/t16-,19+;/m1./s1

SMILES Code: O=C(C1=CN2C3=C(C(N4[C@H](NC([C@H](N)CCC)=O)CCC4)=C(F)C=C3C1=O)OC5=CC=CC=C25)O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 516.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chu DT, Hallas R, Clement JJ, Alder J, McDonald E, Plattner JJ. Synthesis and antitumour activities of quinolone antineoplastic agents. Drugs Exp Clin Res. 1992;18(7):275-82. PubMed PMID: 1338309.

2: Snyder RD. Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35(1):13-21. PubMed PMID: 10692223.

3: Chu DT, Hallas R, Tanaka SK, Alder J, Balli D, Plattner JJ. Synthesis and antitumour activities of tetracyclic quinolone antineoplastic agents. Drugs Exp Clin Res. 1994;20(5):177-83. PubMed PMID: 7875053.

4: Permana PA, Snapka RM, Shen LL, Chu DT, Clement JJ, Plattner JJ. Quinobenoxazines: a class of novel antitumor quinolones and potent mammalian DNA topoisomerase II catalytic inhibitors. Biochemistry. 1994 Sep 20;33(37):11333-9. PubMed PMID: 7727384.