A 70874

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571182

CAS#: 131449-37-1

Description: A 70874 has high potency and selectivity for cholecystokinin (CCK) A receptors.


Chemical Structure

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A 70874
CAS# 131449-37-1

Theoretical Analysis

MedKoo Cat#: 571182
Name: A 70874
CAS#: 131449-37-1
Chemical Formula: C45H55N7O10
Exact Mass: 853.401
Molecular Weight: 853.97
Elemental Analysis: C, 63.29; H, 6.49; N, 11.48; O, 18.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A 70874; A-70874; A70874

IUPAC/Chemical Name: L-Phenylalaninamide, N-((1,1-dimethylethoxy)carbonyl)-L-tryptophyl-N6-(3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-L-lysyl-L-alpha-aspartyl-Nalpha-methyl-

InChi Key: BERNHFOYDVXQGI-ZXLOHXMUSA-N

InChi Code: InChI=1S/C45H55N7O10/c1-45(2,3)62-44(61)51-35(25-30-27-48-33-15-9-8-14-32(30)33)42(59)49-34(16-10-11-23-47-38(54)22-19-28-17-20-31(53)21-18-28)41(58)50-36(26-39(55)56)43(60)52(4)37(40(46)57)24-29-12-6-5-7-13-29/h5-9,12-15,17-22,27,34-37,48,53H,10-11,16,23-26H2,1-4H3,(H2,46,57)(H,47,54)(H,49,59)(H,50,58)(H,51,61)(H,55,56)/b22-19+/t34-,35-,36-,37-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)N(C([C@H](CC(O)=O)NC([C@H](CCCCNC(/C=C/C2=CC=C(O)C=C2)=O)NC([C@H](CC3=CNC4=C3C=CC=C4)NC(OC(C)(C)C)=O)=O)=O)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 853.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lin CW, Shiosaki K, Miller TR, Witte DG, Bianchi BR, Wolfram CA, Kopecka H, Craig R, Wagenaar F, Nadzan AM. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51. PubMed PMID: 1706470.

2: Lin CW, Bianchi BR, Miller TR, Witte DG, Wolfram CA. Both CCK-A and CCK -B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands. Am J Physiol. 1992 Jun;262(6 Pt 1):G1113-20. PubMed PMID: 1616041.

3: Bianchi BR, Miller TR, Witte DG, Lin CW. Novel CCK analogues and bombesin: a detailed analysis between phosphoinositide breakdown and high-dose inhibition of pancreatic enzyme secretion in three rodent species. J Pharmacol Exp Ther. 1994 Feb;268(2):996-1002. PubMed PMID: 7509394.