A71378

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571177

CAS#: 127902-33-4

Description: A71378 is a Cholecystokinin (CCK) receptor agonist with high potency & selectivity for CCK-A receptors.


Chemical Structure

img
A71378
CAS# 127902-33-4

Theoretical Analysis

MedKoo Cat#: 571177
Name: A71378
CAS#: 127902-33-4
Chemical Formula: C48H62N8O13S
Exact Mass: 990.4157
Molecular Weight: 991.13
Elemental Analysis: C, 58.17; H, 6.31; N, 11.31; O, 20.98; S, 3.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: A71378; A-71378; A 71378

IUPAC/Chemical Name: L-Phenylalaninamide, N-(1-oxo-3-(4-(sulfooxy)phenyl)propyl)-L-norleucylglycyl-L-tryptophyl-L-norleucyl-N-methyl-L-alpha-aspartyl-

InChi Key: YJRSAZMDFOJHLB-HECCNADXSA-N

InChi Code: InChI=1S/C48H62N8O13S/c1-4-6-16-36(52-41(57)24-21-30-19-22-33(23-20-30)69-70(66,67)68)45(62)51-29-42(58)53-39(26-32-28-50-35-18-12-11-15-34(32)35)46(63)54-37(17-7-5-2)48(65)56(3)40(27-43(59)60)47(64)55-38(44(49)61)25-31-13-9-8-10-14-31/h8-15,18-20,22-23,28,36-40,50H,4-7,16-17,21,24-27,29H2,1-3H3,(H2,49,61)(H,51,62)(H,52,57)(H,53,58)(H,54,63)(H,55,64)(H,59,60)(H,66,67,68)/t36-,37-,38-,39-,40-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)N(C([C@H](CCCC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)NC(CCC4=CC=C(OS(=O)(O)=O)C=C4)=O)=O)=O)=O)=O)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 991.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Davidowa H, Wetzel K, Henklein P. Neostriatal neurons of rats can be influenced by cholecystokinin-A receptor agonists. Neuropeptides. 1997 Jun;31(3):231-5. PubMed PMID: 9243519.

2: Qian JM, Rowley WH, Jensen RT. Gastrin and CCK activate phospholipase C and stimulate pepsinogen release by interacting with two distinct receptors. Am J Physiol. 1993 Apr;264(4 Pt 1):G718-27. PubMed PMID: 8476056.

3: Davidowa H, Wetzel K, Vierig G. Effects of cholecystokinin agonists on striatal neurons are reduced by acetylcholine. Peptides. 1997;18(4):541-5. PubMed PMID: 9210173.

4: Giralt M, Vergara P. Inhibition by CCK of ascending contraction elicited by mucosal stimulation in the duodenum of the rat. Neurogastroenterol Motil. 2000 Apr;12(2):173-80. PubMed PMID: 10877605.

5: Lin CW, Bianchi BR, Miller TR, Witte DG, Wolfram CA. Both CCK-A and CCK-B/gastrin receptors mediate pepsinogen release in guinea pig gastric glands. Am J Physiol. 1992 Jun;262(6 Pt 1):G1113-20. PubMed PMID: 1616041.

6: Lodge DJ, Lawrence AJ. Comparative analysis of the central CCK system in Fawn Hooded and Wistar Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligand. Regul Pept. 2001 Jun 15;99(2-3):191-201. PubMed PMID: 11384782.

7: Heidel E, Davidowa H. Interactive effects of cholecystokinin-8S and serotonin on spontaneously active neurons in ventromedial hypothalamic slices. Neuropeptides. 1998 Oct;32(5):423-9. PubMed PMID: 9845002.

8: Pradhan TK, Qian JM, Sutliff VE, Mantey SA, Jensen RT. Identification of CCK-A receptors on chief cells with use of a novel, highly selective ligand. Am J Physiol. 1995 Apr;268(4 Pt 1):G605-12. PubMed PMID: 7733286.

9: Tang LH, Miller MD, Goldenring JR, Modlin IM, Hersey SJ. Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion. Am J Physiol. 1993 Nov;265(5 Pt 1):G865-72. PubMed PMID: 8238515.

10: Rex A, Fink H. Effects of cholecystokinin-receptor agonists on cortical 5-HT release in guinea pigs on the X-maze. Peptides. 1998;19(3):519-26. PubMed PMID: 9533640.

11: Dabrowski A, Detjen KM, Logsdon CD, Williams JA. Stimulation of both CCK-A and CCK-B receptors activates MAP kinases in AR42J and receptor-transfected CHO cells. Digestion. 1997;58(4):361-7. PubMed PMID: 9324163.

12: Voits M, Voigt JP, Boomgaarden M, Henklein P, Fink H. Comparison of the satiating effect of the CCKA receptor agonist A71378 with CCK-8S. Peptides. 1996;17(2):355-7. PubMed PMID: 8801546.

13: Parrott RF. Peripheral and central effects of CCK receptor agonists on operant feeding in pigs. Physiol Behav. 1993 Feb;53(2):367-72. PubMed PMID: 8446699.

14: Meyer G, Beinborn M, Sewing KF. Characterization of CCKA receptor mediated pepsinogen secretion in porcine chief cells. Pharmacology. 1996 Jul;53(1):48-59. PubMed PMID: 8875601.

15: Giralt M, Vergara P. Both afferent and efferent nerves are implicated in cholecytokinin motor actions in the small intestine of the rat. Regul Pept. 1999 May 31;81(1-3):73-80. PubMed PMID: 10395411.

16: Lin CW, Holladay MW, Witte DG, Miller TR, Wolfram CA, Bianchi BR, Bennett MJ, Nadzan AM. A71378: a CCK agonist with high potency and selectivity for CCK-A receptors. Am J Physiol. 1990 Apr;258(4 Pt 1):G648-51. PubMed PMID: 2333977.