A 69992

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571170

CAS#: 138921-14-9

Description: A 69992 is an HIV anti-infective nucleoside. Its enantiomers (see Synonyms) also show anti-HIV activity.

Chemical Structure

A 69992
CAS# 138921-14-9

Theoretical Analysis

MedKoo Cat#: 571170
Name: A 69992
CAS#: 138921-14-9
Chemical Formula: C11H14TN5O3
Exact Mass: 267.1257
Molecular Weight: 267.28
Elemental Analysis: C, 49.43; H, 6.41; N, 26.20; O, 17.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A 69992; A-69992; A69992; Abbott 69992; A 75962; A-75962; A75962; A 75179; A75179; A-75179;

IUPAC/Chemical Name: 6H-Purin-6-one-8-t,2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-, (1alpha,2beta,3alpha)-(+-)-


InChi Code: InChI=1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m0/s1/i4T

SMILES Code: O=C1NC(N)=NC2=C1N=C([3H])N2[C@@H]3[C@@H](CO)[C@H](CO)C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 267.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thomas SB, Surber BW. Preparative separation and analysis of the enantiomers of [3H]Abbott-69992, an HIV anti-infective nucleoside, by ligand exchange high-performance liquid chromatography. J Chromatogr. 1991 Nov 22;586(2):265-70. PubMed PMID: 1810972.

2: Kohlbrenner WE, Carter CD, Fesik SW, Norbeck DW, Erickson J. Efficiency of phosphorylation of the cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity. Biochem Pharmacol. 1990 Dec 1;40(11):R5-10. PubMed PMID: 2176497.