A 65317

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571167

CAS#: 122224-84-4

Description: A 65317 is a selective renin inhibitor that causes a blockade of the renin-angiotensin system.


Price and Availability

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A 65317 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 571167
Name: A 65317
CAS#: 122224-84-4
Chemical Formula: C38H58N6O9
Exact Mass: 742.4265
Molecular Weight: 742.92
Elemental Analysis: C, 61.44; H, 7.87; N, 11.31; O, 19.38


Synonym: A 65317; A65317; A-65317

IUPAC/Chemical Name: 1H-Imidazole-4-propanamide, N-(1-(cyclohexylmethyl)-2-(3-ethyl-2-oxo-5-oxazolidinyl)-2-hydroxyethyl)-alpha-((5-methyl-1,4-dioxo-2-(phenylmethyl)-8,10,13-trioxa-5-azatetradec-1-yl)amino)-, (5S-(5R*(1R*(R*(S*)),2S*)))-

InChi Key: JZRFAIHFMIECQR-JAUPOCBBSA-N

InChi Code: InChI=1S/C38H58N6O9/c1-4-44-24-33(53-38(44)49)35(46)31(20-28-13-9-6-10-14-28)41-37(48)32(22-30-23-39-25-40-30)42-36(47)29(19-27-11-7-5-8-12-27)21-34(45)43(2)15-16-51-26-52-18-17-50-3/h5,7-8,11-12,23,25,28-29,31-33,35,46H,4,6,9-10,13-22,24,26H2,1-3H3,(H,39,40)(H,41,48)(H,42,47)/t29-,31+,32-,33+,35?/m1/s1

SMILES Code: O=C(N[C@@H](CC1CCCCC1)C([C@@H]2CN(CC)C(O2)=O)O)[C@H](NC([C@H](CC3=CC=CC=C3)CC(N(C)CCOCOCCOC)=O)=O)CC4=CNC=N4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Verburg KM, Kadam JR, Young GA, Rosenberg SH, Kleinert HD. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259(1 Pt 2):R7-14. PubMed PMID: 2197881.

2: Dayton BD, Stein HH, Cohen J, Baker WR, Boyd SA, Condon SL, Donner BG, Fung AK, Luly JR, Rosenberg SH, et al. Effects of angiotensinase inhibitors on plasma protein binding and IC50 determinations of renin inhibitors. Clin Chem. 1992 Nov;38(11):2239-43. PubMed PMID: 1330373.

3: Kim J, Hughbanks T. Synthesis and structures of new ternary aluminum chalcogenides: LiAlSe2, alpha-LiAlTe2, and beta-LiAlTe2. Inorg Chem. 2000 Jul 10;39(14):3092-7. PubMed PMID: 11196906.