WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 540280

CAS#: 115550-35-1

Description: Marbofloxacin is a bacterial DNA gyrase inhibitor. It suppresses growth of Staphylococus, Escherichia, Actinobacillus, Pasturella, and Mannhemia.

Price and Availability


USD 235

USD 510

Marbofloxacin purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 540280
Name: Marbofloxacin
CAS#: 115550-35-1
Chemical Formula: C17H19FN4O4
Exact Mass: 362.139
Molecular Weight: 362.36
Elemental Analysis: C, 56.35; H, 5.29; F, 5.24; N, 15.46; O, 17.66

Synonym: Marbofloxacin; Zeniquin

IUPAC/Chemical Name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,3,4]oxadiazino[6,5,4-ij]quinoline-6-carboxylic acid


InChi Code: InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


1: Jerzsele Á, Pásztiné-Gere E. Evaluating synergy between marbofloxacin and gentamicin in Pseudomonas aeruginosa strains isolated from dogs with otitis externa. Acta Microbiol Immunol Hung. 2015 Mar;62(1):45-55. doi: 10.1556/AMicr.62.2015.1.4. PubMed PMID: 25823453.

2: Lashev LD, Dimitrova DJ, Milanova A, Moutafchieva RG. Pharmacokinetics of enrofloxacin and marbofloxacin in Japanese quails and common pheasants. Br Poult Sci. 2015 Apr;56(2):255-61. doi: 10.1080/00071668.2014.998989. Epub 2015 Jan 29. PubMed PMID: 25567298.

3: Sun J, Xiao X, Huang RJ, Yang T, Chen Y, Fang X, Huang T, Zhou YF, Liu YH. In vitro Dynamic Pharmacokinetic/Pharmacodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis. BMC Vet Res. 2015 Dec 1;11:293. doi: 10.1186/s12917-015-0604-5. PubMed PMID: 26626889; PubMed Central PMCID: PMC4666160.

4: Qu Y, Qiu Z, Cao C, Lu Y, Sun M, Liang C, Zeng Z. Pharmacokinetics/pharmacodynamics of marbofloxacin in a Pasteurella multocida serious murine lung infection model. BMC Vet Res. 2015 Dec 2;11:294. doi: 10.1186/s12917-015-0608-1. PubMed PMID: 26631082; PubMed Central PMCID: PMC4668604.

5: Yang F, Yang YR, Wang L, Huang XH, Qiao G, Zeng ZL. Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model. J Vet Pharmacol Ther. 2014 Dec;37(6):579-88. doi: 10.1111/jvp.12137.. Epub 2014 Jun 6. PubMed PMID: 24903645.

6: Yohannes S, Hossain MA, Kim JY, Lee SJ, Kwak DM, Suh JW, Park SC. Allometric scaling of marbofloxacin pharmacokinetics: a retrospective analysis. Pol J Vet Sci. 2014;17(1):99-103. PubMed PMID: 24724476.

7: Shan Q, Zheng G, Liu S, Bai Y, Li L, Yin Y, Ma L, Zhu X. Pharmacokinetic/pharmacodynamic relationship of marbofloxacin against Aeromonas hydrophila in Chinese soft-shelled turtles (Trionyx sinensis). J Vet Pharmacol Ther. 2015 Dec;38(6):537-42. doi: 10.1111/jvp.12214. Epub 2015 Feb 18. PubMed PMID: 25694049.

8: Cao C, Qu Y, Sun M, Qiu Z, Huang X, Huai B, Lu Y, Zeng Z. In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves. Front Microbiol. 2015 Jul 24;6:759. doi: 10.3389/fmicb.2015.00759. eCollection 2015. PubMed PMID: 26257726; PubMed Central PMCID: PMC4513234.

9: Yohannes S, Awji EG, Lee SJ, Park SC. Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin after intravenous and intramuscular administration in beagle dogs. Xenobiotica. 2015 Mar;45(3):264-9. doi: 10.3109/00498254.2014.969794. Epub 2014 Dec 3. PubMed PMID: 25470431.

10: Ding H, Wang L, Shen X, Gu X, Zeng D, Zeng Z. Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J Vet Pharmacol Ther. 2013 Oct;36(5):511-5. doi: 10.1111/jvp.12049. Epub 2013 Mar 28. PubMed PMID: 23550715.

11: Schneider M, Paulin A, Dron F, Woehrlé F. Pharmacokinetics of marbofloxacin in pigs after intravenous and intramuscular administration of a single dose of 8 mg/kg: dose proportionality, influence of the age of the animals and urinary elimination. J Vet Pharmacol Ther. 2014 Dec;37(6):523-30. doi: 10.1111/jvp.12125. Epub 2014 Mar 25. PubMed PMID: 24666477; PubMed Central PMCID: PMC4265270.

12: Illambas J, Potter T, Cheng Z, Rycroft A, Fishwick J, Lees P. Pharmacodynamics of marbofloxacin for calf pneumonia pathogens. Res Vet Sci. 2013 Jun;94(3):675-81. doi: 10.1016/j.rvsc.2012.12.012. Epub 2013 Jan 31. PubMed PMID: 23375665.

13: Marín P, Alamo LF, Escudero E, Fernández-Varón E, Hernandis V, Cárceles CM. Pharmacokinetics of marbofloxacin in rabbit after intravenous, intramuscular, and subcutaneous administration. Res Vet Sci. 2013 Jun;94(3):698-700. doi: 10.1016/j.rvsc.2013.01.013. Epub 2013 Feb 20. PubMed PMID: 23434066.

14: Haritova A, Dimitrova D, Dinev T, Moutafchieva R, Lashev L. Comparative pharmacokinetics of enrofloxacin, danofloxacin, and marbofloxacin after intravenous and oral administration in Japanese quail (Coturnix coturnix japonica). J Avian Med Surg. 2013 Mar;27(1):23-31. PubMed PMID: 23772453.

15: Shan Q, Wang J, Yang F, Ding H, Liang C, Lv Z, Li Z, Zeng Z. Pharmacokinetic/pharmacodynamic relationship of marbofloxacin against Pasteurella multocida in a tissue-cage model in yellow cattle. J Vet Pharmacol Ther. 2014 Jun;37(3):222-30. doi: 10.1111/jvp.12078. Epub 2013 Aug 26. PubMed PMID: 24033339.

16: Lallemand E, Trencart P, Tahier C, Dron F, Paulin A, Tessier C. Pharmacokinetics, pharmacodynamics and local tolerance at injection site of marbofloxacin administered by regional intravenous limb perfusion in standing horses. Vet Surg. 2013 Aug;42(6):649-57. doi: 10.1111/j.1532-950X.2013.12030.x. Epub 2013 Jul 25. PubMed PMID: 23889562.

17: Baroni EE, Rubio S, De Lucas JJ, Andrés MD, Andrés MI. Comparison of pharmacokinetics of marbofloxacin after subcutaneous administration of various multiple-dose regimens to water buffalo calves (Bubalus bubalis). Am J Vet Res. 2014 Dec;75(12):1049-55. doi: 10.2460/ajvr.75.12.1049. PubMed PMID: 25419804.

18: Belew S, Kim JY, Hossain MA, Park JY, Lee SJ, Park YS, Suh JW, Kim JC, Park SC. Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration in Hanwoo, Korean native cattle. J Vet Med Sci. 2015 Mar;77(3):327-9. doi: 10.1292/jvms.14-0221. Epub 2014 Nov 18. PubMed PMID: 25411109; PubMed Central PMCID: PMC4383779.

19: Weil C, Tünsmeyer J, Tipold A, Hoppe S, Beyerbach M, Pankow WR, Kästner SB. Effects of concurrent perioperative use of marbofloxacin and cimicoxib or carprofen in dogs. J Small Anim Pract. 2016 Jun;57(6):311-7. doi: 10.1111/jsap.12464. Epub 2016 Mar 31. PubMed PMID: 27029676.

20: Endo Y, Tsuchiya T, Omura T, Nakai K, Korosue K, Ishimaru M, Ishikawa Y, Hobo S. Effects of pre-shipping marbofloxacin administration on fever and blood properties in healthy Thoroughbreds transported a long distance. J Vet Med Sci. 2015 Jan;77(1):75-9. doi: 10.1292/jvms.14-0336. Epub 2014 Oct 29. PubMed PMID: 25720808; PubMed Central PMCID: PMC4349540.