CZC-13788

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561336

CAS#: 1035226-29-9

Description: CZC-13788 is a highly potent and selective H4R antagonist. Pharmacological studies suggest the potential utility of histamine H4R antagonists/inverse agonists in the treatment of inflammatory diseases, e.g. allergic rhinitis, asthma, atopic dermatitis, colitis, or pruritus.


Chemical Structure

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CZC-13788
CAS# 1035226-29-9

Theoretical Analysis

MedKoo Cat#: 561336
Name: CZC-13788
CAS#: 1035226-29-9
Chemical Formula: C15H16ClN5O
Exact Mass: 317.1043
Molecular Weight: 317.78
Elemental Analysis: C, 56.70; H, 5.08; Cl, 11.16; N, 22.04; O, 5.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CZC-13788; CZC 13788; CZC13788

IUPAC/Chemical Name: 7-Chloro-4-(4-methyl-1-piperazinyl)benzofuro[3,2-d]pyrimidin-2-amine

InChi Key: AZIXOGQCOAHTBZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H16ClN5O/c1-20-4-6-21(7-5-20)14-13-12(18-15(17)19-14)10-3-2-9(16)8-11(10)22-13/h2-3,8H,4-7H2,1H3,(H2,17,18,19)

SMILES Code: NC1=NC(N2CCN(C)CC2)=C(OC3=CC(Cl)=CC=C34)C4=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 317.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lazewska D, Kiec-Kononowicz K. Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87. Review. PubMed PMID: 22202103.