WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561335
Description: MRT199665 is a novel inhibitor of salt-inducible kinases (SIKs). MRT199665 increases IL-10 production while suppressing IL-6, IL-12, and TNF secretion.
MedKoo Cat#: 561335
Chemical Formula: C18H19N3O4S
Exact Mass: 373.1096
Molecular Weight: 373.43
Elemental Analysis: C, 57.90; H, 5.13; N, 11.25; O, 17.14; S, 8.59
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: MRT199665; MRT-199665; MRT 199665;
IUPAC/Chemical Name: 7-[(1S)-4-Hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
InChi Key: LZUYOYKXEXENTQ-ZDUSSCGKSA-N
InChi Code: InChI=1S/C18H19N3O4S/c1-18(2)12-9-19-17(26(3,24)25)20-15(12)21(16(18)23)13-8-7-11-10(13)5-4-6-14(11)22/h4-6,9,13,22H,7-8H2,1-3H3/t13-/m0/s1
SMILES Code: O=C1C(C)(C)C2=CN=C(S(=O)(C)=O)N=C2N1[C@H]3CCC4=C3C=CC=C4O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 373.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ross FA, Hawley SA, Auciello FR, Gowans GJ, Atrih A, Lamont DJ, Hardie DG. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chem Biol. 2017 Jul 20;24(7):813-824.e4. doi: 10.1016/j.chembiol.2017.05.021. Epub 2017 Jun 15. PubMed PMID: 28625738; PubMed Central PMCID: PMC5522529.
2: Darling NJ, Toth R, Arthur JS, Clark K. Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. Biochem J. 2017 Feb 15;474(4):521-537. doi: 10.1042/BCJ20160646. Epub 2016 Dec 5. PubMed PMID: 27920213; PubMed Central PMCID: PMC5290485.
3: Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: 10.1073/pnas.1215450109. Epub 2012 Oct 2. PubMed PMID: 23033494; PubMed Central PMCID: PMC3479463.