A 55453

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571141

CAS#: 89687-06-9

Description: A 55453 is a radiated ionophore used as a high-affinity alpha 1-adrenergic receptor probe. It is a ligand that binds reversibly to rat hepatic plasma membranes with high affinity; thus it can be useful for the molecular characterization of alpha 1-adrenergic receptors in tissues.


Chemical Structure

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A 55453
CAS# 89687-06-9

Theoretical Analysis

MedKoo Cat#: 571141
Name: A 55453
CAS#: 89687-06-9
Chemical Formula: C25H32N6O3
Exact Mass: 464.2536
Molecular Weight: 464.57
Elemental Analysis: C, 64.64; H, 6.94; N, 18.09; O, 10.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: A55453; A 55453; A-55453

IUPAC/Chemical Name: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(5-(4-aminophenyl)-1-oxopentyl)-

InChi Key: ASWMBQMBNVJRQF-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32N6O3/c1-33-21-15-19-20(16-22(21)34-2)28-25(29-24(19)27)31-13-11-30(12-14-31)23(32)6-4-3-5-17-7-9-18(26)10-8-17/h7-10,15-16H,3-6,11-14,26H2,1-2H3,(H2,27,28,29)

SMILES Code: O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)CCCCC4=CC=C(N)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 464.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dickinson KE, Leeb-Lundberg LM, Heald SL, Wikberg JE, DeBernardis JF, Caron MG, Lefkowitz RJ. Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. Mol Pharmacol. 1984 Sep;26(2):187-95. PubMed PMID: 6090880.