WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571141
Description: A 55453 is a radiated ionophore used as a high-affinity alpha 1-adrenergic receptor probe. It is a ligand that binds reversibly to rat hepatic plasma membranes with high affinity; thus it can be useful for the molecular characterization of alpha 1-adrenergic receptors in tissues.
MedKoo Cat#: 571141
Name: A 55453
Chemical Formula: C25H32N6O3
Exact Mass: 464.2536
Molecular Weight: 464.57
Elemental Analysis: C, 64.64; H, 6.94; N, 18.09; O, 10.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: A55453; A 55453; A-55453
IUPAC/Chemical Name: Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(5-(4-aminophenyl)-1-oxopentyl)-
InChi Key: ASWMBQMBNVJRQF-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H32N6O3/c1-33-21-15-19-20(16-22(21)34-2)28-25(29-24(19)27)31-13-11-30(12-14-31)23(32)6-4-3-5-17-7-9-18(26)10-8-17/h7-10,15-16H,3-6,11-14,26H2,1-2H3,(H2,27,28,29)
SMILES Code: O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)CCCCC4=CC=C(N)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 464.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dickinson KE, Leeb-Lundberg LM, Heald SL, Wikberg JE, DeBernardis JF, Caron MG, Lefkowitz RJ. Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors. Mol Pharmacol. 1984 Sep;26(2):187-95. PubMed PMID: 6090880.