WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571139
CAS#: 87896-52-4 (A)
Description: A 58365 A is an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus. It is used to treat hypertension and congestive heart failure.
MedKoo Cat#: 571139
Name: A 58365 A
CAS#: 87896-52-4 (A)
Chemical Formula: C12H13NO6
Exact Mass: 267.0743
Molecular Weight: 267.24
Elemental Analysis: C, 53.93; H, 4.90; N, 5.24; O, 35.92
This product is not in stock, which may be available by custom synthesis.
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Synonym: A 58365A; A-58365A; A58365A
IUPAC/Chemical Name: 6-Indolizinepropanoic acid, 3-carboxy-1,2,3,5-tetrahydro-8-hydroxy-5-oxo-, (-)-
InChi Key: HMWIHWAAIYAMFZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13NO6/c14-9-5-6(1-4-10(15)16)11(17)13-7(9)2-3-8(13)12(18)19/h5,8,14H,1-4H2,(H,15,16)(H,18,19)
SMILES Code: O=C(O)CCC1=CC(O)=C2CCC(C(O)=O)N2C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 267.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Vinazzer H, Farine JC. Double-blind cross-over study of the effect of sultosilic acid piperazine salt (A-585) and bezafibrate in primary hyperlipoproteinemia. Atherosclerosis. 1983 Nov;49(2):109-18. PubMed PMID: 6686778.
2: Vinazzer H. [Comparison of the antilipemic effect of bezafibrate with that of piperazine-sultosilate (A 585). A crossed double-blind study]. Wien Klin Wochenschr. 1984 Dec 21;96(24):889-93. German. PubMed PMID: 6152088.
3: Rodríguez L, Demestre I, Sagarra R, Laporte J, Esteve A. [Toxicologic study of piperazine sultosylate (A-585)]. Arch Farmacol Toxicol. 1979 Dec;5(3):281-3.Spanish. PubMed PMID: 546355.
4: Casellas Bernat A, Ribas Grau M, Casellas Bernat G, Riera de Barcia L, Alou Llado M, Solivellas Antich S. [Clinical effectiveness of piperazine sultosylate in the hyperlipidemias]. Rev Clin Esp. 1981 Apr 25;161(1):5-8. Spanish. PubMed PMID: 7255818.
5: Rodríguez L, Roser R, Palacios G, Sagarra R, Esteve A. [Hypolipemic activity of piperazine sultosylate (A-585) in the rat and chicken]. Arch Farmacol Toxicol. 1979 Dec;5(3):272-4. Spanish. PubMed PMID: 546353.
6: Rodríguez L, Parés S, Laporte J, Roser R, Esteve J. [Effect of piperazine sultosylate (A-585) on hypertriglyceridemia induced by ethanol in man]. Arch Farmacol Toxicol. 1979 Dec;5(3):235-7. Spanish. PubMed PMID: 546346.
7: Masana L, Villoria J, Sust M, Ros E, Plana N, Pérez-Jiménez F, Franco M, Oliván JJ, Pintó X, Videla S. Treatment of type IIb familial combined hyperlipidemia with the combination pravastatin-piperazine sultosilate. Eur J Pharmacol. 2004 Aug 2;496(1-3):205-12. PubMed PMID: 15288592.