BIPM

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561332

CAS#: 1070424-33-7

Description: BIPM novel and potent Rho-associated protein kinase 2 (ROCK2) inhibitor. Exposure of SH-SY5Y cells to BIPM led to significant changes in neurite length, cell migration and actin stress fibers. Further experiments demonstrated that BIPM was able to significantly inhibit phosphorylation of cofilin, a regulatory protein of actin cytoskeleton.

Chemical Structure

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BIPM
CAS# 1070424-33-7
Instruction

Theoretical Analysis

MedKoo Cat#: 561332
Name: BIPM
CAS#: 1070424-33-7
Chemical Formula: C23H22N2O3
Exact Mass: 374.16
Molecular Weight: 374.440
Elemental Analysis: C, 73.78; H, 5.92; N, 7.48; O, 12.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BIPM;

IUPAC/Chemical Name: 1,3-Benzodioxol-5-yl[1-(5-isoquinolinylmethyl)-3-piperidinyl]-methanone

InChi Key: FVXLGQXTXCJFGL-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N2O3/c26-23(16-6-7-21-22(11-16)28-15-27-21)19-5-2-10-25(14-19)13-18-4-1-3-17-12-24-9-8-20(17)18/h1,3-4,6-9,11-12,19H,2,5,10,13-15H2

SMILES Code: O=C(C1=CC=C(OCO2)C2=C1)C3CN(CC4=CC=CC5=C4C=CN=C5)CCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chong CM, Kou MT, Pan P, Zhou H, Ai N, Li C, Zhong HJ, Leung CH, Hou T, Lee SM. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening. Mol Biosyst. 2016 Aug 16;12(9):2713-21. doi: 10.1039/c6mb00343e. PubMed PMID: 27354305.