NITD008
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561315

CAS#: 1044589-82-3

Description: NITD008 is an antiviral drug. It was developed as a potential treatment for flavivirus infections, and shows broad spectrum antiviral activity against many related viruses such as Dengue virus, West Nile virus, yellow fever virus, Powassan virus, Hepatitis C virus, Kyasanur Forest disease virus, Omsk hemorrhagic fever virus and Zika virus. Unfortunately NITD008 proved too toxic in pre-clinical animal testing to be suitable for human trials, but it continues to be used in research to find improved treatments for emerging viral diseases.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 320 2 Weeks
25mg USD 1010 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-23. Prices are subject to change without notice.

NITD008, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 561315
Name: NITD008
CAS#: 1044589-82-3
Chemical Formula: C13H14N4O4
Exact Mass: 290.1015
Molecular Weight: 290.28
Elemental Analysis: C, 53.79; H, 4.86; N, 19.30; O, 22.05


Synonym: NITD008; NITD 008; NITD-008;

IUPAC/Chemical Name: (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)oxolane-3,4-diol

InChi Key: NKRAIOQPSBRMOV-NRMKKVEVSA-N

InChi Code: InChI=1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1

SMILES Code: O[C@@]1(C#C)[C@H](N2C=CC3=C(N)N=CN=C32)O[C@H](CO)[C@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Deng CL, Zhang QY, Chen DD, Liu SQ, Qin CF, Zhang B, Ye HQ. Recovery of the Zika virus through an in vitro ligation approach. J Gen Virol. 2017 Jul;98(7):1739-1743. doi: 10.1099/jgv.0.000862. Epub 2017 Jul 13. PubMed PMID: 28703698.

2: Ali A, Wahid B, Rafique S, Idrees M. Advances in research on Zika virus. Asian Pac J Trop Med. 2017 Apr;10(4):321-331. doi: 10.1016/j.apjtm.2017.03.020. Epub 2017 Apr 6. Review. PubMed PMID: 28552102.

3: Zhang HL, Ye HQ, Deng CL, Liu SQ, Shi PY, Qin CF, Yuan ZM, Zhang B. Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening. Antiviral Res. 2017 May;141:38-47. doi: 10.1016/j.antiviral.2017.02.006. Epub 2017 Feb 13. PubMed PMID: 28202375.

4: Adcock RS, Chu YK, Golden JE, Chung DH. Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay. Antiviral Res. 2017 Feb;138:47-56. doi: 10.1016/j.antiviral.2016.11.018. Epub 2016 Dec 3. PubMed PMID: 27919709.

5: Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, Shi PY, Qin CF. Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus. Open Forum Infect Dis. 2016 Aug 30;3(4):ofw175. eCollection 2016 Oct. PubMed PMID: 27747251; PubMed Central PMCID: PMC5063548.

6: Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF. In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. Antiviral Res. 2016 Jun;130:46-9. doi: 10.1016/j.antiviral.2016.03.013. Epub 2016 Mar 23. PubMed PMID: 27016316; PubMed Central PMCID: PMC5096641.

7: Qing J, Luo R, Wang Y, Nong J, Wu M, Shao Y, Tang R, Yu X, Yin Z, Sun Y. Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus. Antiviral Res. 2016 Feb;126:43-54. doi: 10.1016/j.antiviral.2015.12.010. Epub 2015 Dec 24. PubMed PMID: 26724382.

8: Nelson J, Roe K, Orillo B, Shi PY, Verma S. Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection. Antiviral Res. 2015 Oct;122:39-45. doi: 10.1016/j.antiviral.2015.07.008. Epub 2015 Jul 29. PubMed PMID: 26225754; PubMed Central PMCID: PMC4853296.

9: Deng C, Li X, Liu S, Xu L, Ye H, Qin CF, Zhang B. Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone. Virol Sin. 2015 Aug;30(4):269-76. doi: 10.1007/s12250-015-3610-7. Epub 2015 Jul 24. PubMed PMID: 26220729.

10: Shang L, Wang Y, Qing J, Shu B, Cao L, Lou Z, Gong P, Sun Y, Yin Z. An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation. Antiviral Res. 2014 Dec;112:47-58. doi: 10.1016/j.antiviral.2014.10.009. Epub 2014 Oct 23. PubMed PMID: 25446894.

11: Deng CL, Yeo H, Ye HQ, Liu SQ, Shang BD, Gong P, Alonso S, Shi PY, Zhang B. Inhibition of enterovirus 71 by adenosine analog NITD008. J Virol. 2014 Oct;88(20):11915-23. doi: 10.1128/JVI.01207-14. Epub 2014 Aug 6. PubMed PMID: 25100827; PubMed Central PMCID: PMC4178731.

12: Chen YL, Abdul Ghafar N, Karuna R, Fu Y, Lim SP, Schul W, Gu F, Herve M, Yokohama F, Wang G, Cerny D, Fink K, Blasco F, Shi PY. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol. 2014 Feb;88(3):1740-7. doi: 10.1128/JVI.02841-13. Epub 2013 Nov 20. PubMed PMID: 24257621; PubMed Central PMCID: PMC3911617.

13: Shan C, Li X, Deng C, Shang B, Xu L, Ye H, Yuan Z, Zhang B. Development and characterization of West Nile virus replicon expressing secreted Gaussia luciferase. Virol Sin. 2013 Jun;28(3):161-6. doi: 10.1007/s12250-013-3332-7. Epub 2013 May 25. PubMed PMID: 23709059.

14: Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, Kondreddi RR, Niyomrattanakit P, Lakshminarayana SB, Goh A, Xu HY, Liu W, Liu B, Lim JY, Ng CY, Qing M, Lim CC, Yip A, Wang G, Chan WL, Tan HP, Lin K, Zhang B, Zou G, Bernard KA, Garrett C, Beltz K, Dong M, Weaver M, He H, Pichota A, Dartois V, Keller TH, Shi PY. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. doi: 10.1073/pnas.0907010106. Epub 2009 Nov 16. PubMed PMID: 19918064; PubMed Central PMCID: PMC2787148.