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MedKoo CAT#: 571086

CAS#: 50686-98-1

Description: A25822B is an antifungal agent. It is an azasterol that may decrease the ratio of unsaturated to saturated fatty acids.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-11-23. Prices are subject to change without notice.

A25822B is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 571086
Name: A25822B
CAS#: 50686-98-1
Chemical Formula: C28H45NO
Exact Mass: 411.3501
Molecular Weight: 411.67
Elemental Analysis: C, 81.69; H, 11.02; N, 3.40; O, 3.89

Synonym: A25822B

IUPAC/Chemical Name: (1R,6aS,8S,10aR,12aS)-10a,12a-dimethyl-1-((R)-6-methyl-5-methyleneheptan-2-yl)-1,2,3,5,6,6a,7,8,9,10,10a,11,12,12a-tetradecahydronaphtho[1,2-h]quinolin-8-ol


InChi Code: InChI=1S/C28H45NO/c1-18(2)19(3)7-8-20(4)24-13-16-29-26-23-10-9-21-17-22(30)11-14-27(21,5)25(23)12-15-28(24,26)6/h18,20-22,24,30H,3,7-17H2,1-2,4-6H3/t20-,21+,22+,24-,27-,28+/m1/s1

SMILES Code: C[C@@]12CC[C@H](O)C[C@@H]1CCC3=C2CC[C@@]4(C)[C@@H]([C@H](C)CCC(C(C)C)=C)CCN=C34

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Georgopapadakou NH, Dix BA, Smith SA, Freudenberger J, Funke PT. Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans. Antimicrob Agents Chemother. 1987 Jan;31(1):46-51. PubMed PMID: 3551826; PubMed Central PMCID: PMC174649.

2: Jančič S, Frisvad JC, Kocev D, Gostinčar C, Džeroski S, Gunde-Cimerman N. Production of Secondary Metabolites in Extreme Environments: Food- and Airborne Wallemia spp. Produce Toxic Metabolites at Hypersaline Conditions. PLoS One. 2016 Dec 30;11(12):e0169116. doi: 10.1371/journal.pone.0169116. eCollection 2016. PubMed PMID: 28036382; PubMed Central PMCID: PMC5201246.

3: Michel KH, Hamill RL, Larsen SH, Williams RH. New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. II. Isolation and characterization. J Antibiot (Tokyo). 1975 Feb;28(2):102-11. PubMed PMID: 1167541.

4: Gordee RS, Butler TF. New azasteroidal antifungal antibiotics from Geotrichum flavo-brunneum. III. Biological activity. J Antibiot (Tokyo). 1975 Feb;28(2):112-7. PubMed PMID: 1089623.

5: Kasbekar DP, Papavinasasundaram KG. An inducible, nondegradative phytoalexin resistance mechanism in Dictyostelium discoideum is suppressed by mutations that alter membrane sterol composition. Appl Environ Microbiol. 1992 Jun;58(6):2071-4. PubMed PMID: 1622285; PubMed Central PMCID: PMC195728.

6: Schrick K, Mayer U, Martin G, Bellini C, Kuhnt C, Schmidt J, Jürgens G. Interactions between sterol biosynthesis genes in embryonic development of Arabidopsis. Plant J. 2002 Jul;31(1):61-73. PubMed PMID: 12100483.

7: Parks LW, Rodríguez RJ. The biochemical action of the azasteroid antibiotics. Biochem Soc Trans. 1983 Dec;11(6):656. PubMed PMID: 6667771.

8: Rodriguez RJ, Parks LW. Physiological response of Saccharomyces cerevisiae to 15-azasterol-mediated growth inhibition. Antimicrob Agents Chemother. 1981 Aug;20(2):184-9. PubMed PMID: 7025753; PubMed Central PMCID: PMC181661.

9: Taylor FR, Rodriguez RJ, Parks LW. Relationship between antifungal activity and inhibition of sterol biosynthesis in miconazole, clotrimazole, and 15-azasterol. Antimicrob Agents Chemother. 1983 Apr;23(4):515-21. PubMed PMID: 6344784; PubMed Central PMCID: PMC184691.

10: Takahashi I, Maruta R, Ando K, Yoshida M, Iwasaki T, Kanazawa J, Okabe M, Tamaoki T. UCA1064-B, a new antitumor antibiotic isolated from Wallemia sebi: production, isolation and structural determination. J Antibiot (Tokyo). 1993 Aug;46(8):1312-4. PubMed PMID: 8407596.

11: Haughan PA, Chance ML, Goad LJ. Effects of an azasterol inhibitor of sterol 24-transmethylation on sterol biosynthesis and growth of Leishmania donovani promastigotes. Biochem J. 1995 May 15;308 ( Pt 1):31-8. PubMed PMID: 7755579; PubMed Central PMCID: PMC1136839.

12: Rodriguez RJ, Parks LW. Growth and antifungal homoazasterol production in Geotrichum flavo-brunneum. Antimicrob Agents Chemother. 1980 Nov;18(5):822-8. PubMed PMID: 7192535; PubMed Central PMCID: PMC284097.