C012 Dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 561275

CAS#: 1219163-50-4

Description: C012 Dihydrochloride is a novel small molecule compound which sensitized BRAF wild-type melanoma cells to vemurafenib. C012 Dihydrochloride significantly reduced melanoma cell viability, with limited toxicity for normal human fibroblasts.


Chemical Structure

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C012 Dihydrochloride
CAS# 1219163-50-4

Theoretical Analysis

MedKoo Cat#: 561275
Name: C012 Dihydrochloride
CAS#: 1219163-50-4
Chemical Formula: C23H30Cl2N4O
Exact Mass: 448.18
Molecular Weight: 449.420
Elemental Analysis: C, 61.47; H, 6.73; Cl, 15.78; N, 12.47; O, 3.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: C012 Dihydrochloride; C-012 Dihydrochloride; C 012 Dihydrochloride; C012 2HCl; C 012 2HCl; C-012 2HCl;

IUPAC/Chemical Name: {2-[2-(4-Ethoxy-phenyl)-1,3a,8-triaza-cyclopenta[a]inden-8-yl]-ethyl}-diethyl-amine dihydrochloride

InChi Key: ILZRHCYMKHAQQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H28N4O.2ClH/c1-4-25(5-2)15-16-26-21-9-7-8-10-22(21)27-17-20(24-23(26)27)18-11-13-19(14-12-18)28-6-3;;/h7-14,17H,4-6,15-16H2,1-3H3;2*1H

SMILES Code: CCN(CCN1C2=NC(C3=CC=C(OCC)C=C3)=CN2C4=C1C=CC=C4)CC.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 449.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sutton SK, Carter DR, Kim P, et al. A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner. Oncotarget. 2016;7(32):52166-52178. doi:10.18632/oncotarget.10700.