WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561262
CAS#: 423731-10-6
Description: H8-A5 is a novel HDAC8 inhibitor. H8-A5 is selective for HDAC8 over HDAC 1/4 and shows antiproliferation activity in MDA-MB-231 cancer cells.
MedKoo Cat#: 561262
Name: H8-A5
CAS#: 423731-10-6
Chemical Formula: C14H9F3N2O2S
Exact Mass: 326.0337
Molecular Weight: 326.29
Elemental Analysis: C, 51.53; H, 2.78; F, 17.47; N, 8.59; O, 9.81; S, 9.83
This product is not in stock, which may be available by custom synthesis.
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Synonym: H8-A5; H8A5; H8 A5
IUPAC/Chemical Name: 1-[5-[(1H-Benzimidazol-2-ylthio)methyl]-2-furanyl]-2,2,2-trifluoro-ethanone
InChi Key: LJIAJZCOCKLBGW-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H9F3N2O2S/c15-14(16,17)12(20)11-6-5-8(21-11)7-22-13-18-9-3-1-2-4-10(9)19-13/h1-6H,7H2,(H,18,19)
SMILES Code: FC(F)(F)C(C1=CC=C(CSC2=NC3=CC=CC=C3N2)O1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 326.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hou X, Du J, Liu R, Zhou Y, Li M, Xu W, Fang H. Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8. J Chem Inf Model. 2015 Apr 27;55(4):861-71. doi: 10.1021/ci500762z. Epub 2015 Mar 16. PubMed PMID: 25757142.
