WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 561252
CAS#: 1646795-59-6
Description: KC01 is a covalent inhibitor of ABHD16A. ABHD16A is a phosphatidylserine (PS) lipase that generates lyso-PS in mammalian systems. KC01 can deplete lysoPSs from cells, including lymphoblasts derived from subjects with PHARC.
MedKoo Cat#: 561252
Name: KC01
CAS#: 1646795-59-6
Chemical Formula: C22H39NO3
Exact Mass: 365.293
Molecular Weight: 365.56
Elemental Analysis: C, 72.28; H, 10.75; N, 3.83; O, 13.13
Synonym: KC01; K C01; K-C01
IUPAC/Chemical Name: (Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide
InChi Key: RJBBAPPWVJEOMC-MNDPQUGUSA-N
InChi Code: InChI=1S/C22H39NO3/c1-2-3-4-5-6-7-8-9-10-11-14-17-20-19(22(25)26-20)16-13-12-15-18-21(23)24/h16,20H,2-15,17-18H2,1H3,(H2,23,24)/b19-16-
SMILES Code: O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O
1. Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11(2):164-71.
2. Parsons, William H.; Kolar, Matthew J.; Kamat, Siddhesh S.; Cognetta, Armand B., III; Hulce, Jonathan J.; Saez, Enrique; Kahn, Barbara B.; Saghatelian, Alan; Cravatt, Benjamin F. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nature Chemical Biology (2016), 12(5), 367-372.
